The impact of mitotic errors on cell proliferation and tumorigenesis

Mitosis is a delicate event that must be executed with high fidelity to ensure genomic stability. Recent work has provided insight into how mitotic errors shape cancer genomes by driving both numerical and structural alterations in chromosomes that contribute to tumor initiation and progression. Her...

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Bibliographic Details
Published inGenes & development Vol. 32; no. 9-10; pp. 620 - 638
Main Authors Levine, Michelle S., Holland, Andrew J.
Format Journal Article
LanguageEnglish
Published United States Cold Spring Harbor Laboratory Press 01.05.2018
Subjects
Carcinogenesis - genetics
Cell Proliferation - genetics
Cell Transformation, Neoplastic - genetics
Chromosome Aberrations
Chromosome Segregation
Genomic Instability - genetics
Humans
Immunotherapy
Mitosis
Neoplasms - genetics
Neoplasms - therapy
Review
Tumor Microenvironment - genetics
aneuploidy
mitosis
chromosomal instability
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ISSN0890-9369
1549-5477
1549-5477
DOI10.1101/gad.314351.118

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Summary:Mitosis is a delicate event that must be executed with high fidelity to ensure genomic stability. Recent work has provided insight into how mitotic errors shape cancer genomes by driving both numerical and structural alterations in chromosomes that contribute to tumor initiation and progression. Here, we review the sources of mitotic errors in human tumors and their effect on cell fitness and transformation. We discuss new findings that suggest that chromosome missegregation can produce a proinflammatory environment and impact tumor responsiveness to immunotherapy. Finally, we survey the vulnerabilities exposed by cell division errors and how they can be exploited therapeutically.
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ISSN:0890-9369
1549-5477
1549-5477
DOI:10.1101/gad.314351.118