Plasma nitriding under low temperature improves the endothelial cell biocompatibility of 316L stainless steel

• Published in: Biotechnology letters Vol. 41; no. 4-5; pp. 503 - 510
• Main Authors: Braz, Janine K. F. S., Martins, Gabriel M., Sabino, Vladimir, Vitoriano, Jussier O., Barboza, Carlos Augusto G., Soares, Ana Katarina M. C., Rocha, Hugo A. O., Oliveira, Moacir. F., Alves Júnior, Clodomiro, Moura, Carlos Eduardo B.
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 01.05.2019; Springer Nature B.V
• Subjects: Aorta; Apoptosis; Applied Microbiology; Austenitic stainless steels; Biochemistry; Biocompatibility; Biomedical and Life Sciences; Biotechnology; Cell viability; Endothelial cells; Implants; Ion nitriding; Life Sciences; Low temperature; Microbiology; Original Research Paper; Stainless steel; Stents; Surface treatment; Surgical implants; Temperature effects; X-ray diffraction; Biomaterial; Intravascular devices; Metal surfaces; Stents; Nitrited
• ISSN: 0141-5492; 1573-6776
• DOI: 10.1007/s10529-019-02657-7

Objectives To evaluate the effects of the surface modification of 316L stainless steel (SS) by low-temperature plasma nitriding on endothelial cells for stent applications. Results X-ray diffraction (XRD) confirmed the incorporation of nitrogen into the treated steel. The surface treatment significantly increased SS roughness and hydrophilic characteristics. After 4 h the cells adhered to the nitride surfaces and formed clusters. During the 24 h incubation period, cell viability on the nitrided surface was higher compared to the polished surface. Nitriding reduced late apoptosis of rabbit aorta endothelial cell (RAEC) on the SS surface. Conclusion Low temperature plasma nitriding improved the biocompatible of stainless steel for use in stents.