Comparison of disinfectants-induced gene expression profile: Potential adverse effects

Despite their importance in combating the spread of the COVID-19 pandemic, adverse effects of disinfectants on human health, especially the respiratory system, have been of continuing concern to researchers. Considering that bronchi are the main target of sprayed disinfectants, we here treated the s...

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Bibliographic Details
Published inToxicology and applied pharmacology Vol. 470; p. 116546
Main Authors Park, Eun-Jung, Jin, Seung-Woo, Shim, Ilseob, Cho, Art E.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.07.2023
Subjects
Cell death
COVID-19
Disinfectants
Disinfectants - toxicity
Drug-Related Side Effects and Adverse Reactions
Ferroptosis
Guanidines - toxicity
Humans
Inhalation
Microarray
Mode of action
Pandemics
Transcriptome
Ferroptosis
Disinfectants
Microarray
Cell death
Inhalation
Mode of action
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Summary:Despite their importance in combating the spread of the COVID-19 pandemic, adverse effects of disinfectants on human health, especially the respiratory system, have been of continuing concern to researchers. Considering that bronchi are the main target of sprayed disinfectants, we here treated the seven major active ingredients in disinfectant products accepted by the US EPA to human bronchial epithelial cells and determined the subtoxic levels. Then, we performed microarray analysis using total RNA obtained at the subtoxic level and designed a network representing disinfectant-induced cellular response using the KEGG pathway analysis technique. Polyhexamethylguanidine phosphate, a lung fibrosis inducer, was used as a reference material to verify the relationship between cell death and pathology. The derived results reveal potential adverse effects along with the need for an effective application strategy for each chemical. •To date, US EPA accepted sales of 660 disinfectants with 35 active ingredients.•Among them, seven active ingredients contained in most products were selected.•We treated them to human bronchial epithelial cells, a main target of disinfectants.•Changes in gene profile were investigated at the subtoxic level of each ingredient.•Potential adverse effects and the need for an effective application strategy were suggested.
Bibliography:ObjectType-Article-1
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ISSN:0041-008X
1096-0333
DOI:10.1016/j.taap.2023.116546