Anti-obesity effects of black ginseng extract in high fat diet-fed mice

• Published in: Journal of ginseng research Vol. 37; no. 3; pp. 308 - 314
• Main Authors: Lee, Mi Ra, Kim, Byung Chan, Kim, Ran, Oh, Hyun In, Kim, Hyun Kyoung, Choi, Kang Ju, Sung, Chang Keun
• Format: Journal Article
• Language: English
• Published: Korea (South) 고려인삼학회 01.07.2013; The Korean Society of Ginseng
• Subjects: 기타의약학; Obesity; Black ginseng; Hyperlipidemia; Panax ginseng; High fat diet
• ISSN: 1226-8453; 2093-4947
• DOI: 10.5142/jgr.2013.37.308

Black ginseng is produced by a repeated steaming process. The aim of this study was to investigate the anti-obesity effects of black ginseng ethanol extract (BG-EE) in high fat (HF) diet-fed mice. Two groups were fed either a normal control (NC) diet or a HF diet (45% kcal fat). The other three groups were given a HF diet supplemented with 1% BG-EE, 3% BG-EE, and 5% BG-EE for 12 wk. The anti-obesity effects of the BG-EE supplement on body weight, the development of fat mass, and lipid mechanisms were assessed in obese mice. HF-induced hyperlipidemia, fat accumulation in the liver, and white adipose tissues were reduced after BG-EE supplementation. Total fecal weight and the amount of fecal fat excretion also were increased after BG-EE supplementation. These results suggest that BG-EE may be useful to ameliorate HF-induced obesity through the strong inhibition of fat digestion.