Antifungal Combinations for Treatment of Cryptococcal Meningitis in Africa

• Published in: The New England journal of medicine Vol. 378; no. 11; pp. 1004 - 1017
• Main Authors: Molloy, Síle F, Kanyama, Cecilia, Heyderman, Robert S, Loyse, Angela, Kouanfack, Charles, Chanda, Duncan, Mfinanga, Sayoki, Temfack, Elvis, Lakhi, Shabir, Lesikari, Sokoine, Chan, Adrienne K, Stone, Neil, Kalata, Newton, Karunaharan, Natasha, Gaskell, Kate, Peirse, Mary, Ellis, Jayne, Chawinga, Chimwemwe, Lontsi, Sandrine, Ndong, Jean-Gilbert, Bright, Philip, Lupiya, Duncan, Chen, Tao, Bradley, John, Adams, Jack, van der Horst, Charles, van Oosterhout, Joep J, Sini, Victor, Mapoure, Yacouba N, Mwaba, Peter, Bicanic, Tihana, Lalloo, David G, Wang, Duolao, Hosseinipour, Mina C, Lortholary, Olivier, Jaffar, Shabbar, Harrison, Thomas S
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 15.03.2018
• Subjects: Administration, Oral; Adult; Africa - epidemiology; AIDS-Related Opportunistic Infections - drug therapy; Amphotericin B; Amphotericin B - administration & dosage; Amphotericin B - adverse effects; Antifungal agents; Antifungal Agents - adverse effects; Antifungal Agents - therapeutic use; Antigens; Arid zones; Body weight; Clinical trials; Drug Administration Schedule; Drug dosages; Drug Therapy, Combination; Fatalities; Female; Fluconazole; Fluconazole - administration & dosage; Fluconazole - adverse effects; Flucytosine; Flucytosine - administration & dosage; Flucytosine - adverse effects; Health risk assessment; HIV; HIV Seropositivity - complications; Human immunodeficiency virus; Humans; Induction therapy; Infections; Infectious diseases; Kaplan-Meier Estimate; Laboratories; Male; Medical research; Medicine; Meningitis; Meningitis, Cryptococcal - drug therapy; Meningitis, Cryptococcal - mortality; Mortality; Patients; Proportional Hazards Models; Teaching hospitals; Washington DC; Cameroon; United Kingdom > UK; Malawi; United States > US; Africa; Tanzania; Zambia
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa1710922

Globally, cryptococcal meningitis is a leading cause of mortality among people with AIDS, despite the availability of effective amphotericin B–based therapy. In this trial in sub-Saharan Africa, the efficacy of two simpler treatment regimens was assessed.