Brain lipidomics: From functional landscape to clinical significance

Lipids are crucial components of cellular function owing to their role in membrane formation, intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid dysregulations have been associated with the etiology and progression of neurodegeneration and other neurological pa...

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Published inScience advances Vol. 8; no. 37; p. eadc9317
Main Authors Yoon, Jong Hyuk, Seo, Youngsuk, Jo, Yeon Suk, Lee, Seulah, Cho, Eunji, Cazenave-Gassiot, Amaury, Shin, Yong-Seung, Moon, Myeong Hee, An, Hyun Joo, Wenk, Markus R., Suh, Pann-Ghill
Format Journal Article
LanguageEnglish
Published United States American Association for the Advancement of Science 16.09.2022
Subjects
Artificial Intelligence
Brain
Brain Diseases - diagnosis
Brain Diseases - etiology
Developmental Neuroscience
Humans
Lipid Metabolism
Lipidomics
Lipids - chemistry
Network Science
Neuroscience
Review
SciAdv reviews
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Abstract Lipids are crucial components of cellular function owing to their role in membrane formation, intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid dysregulations have been associated with the etiology and progression of neurodegeneration and other neurological pathologies. Hence, brain lipids are emerging as important potential targets for the early diagnosis and prognosis of neurological diseases. This review aims to highlight the significance and usefulness of lipidomics in diagnosing and treating brain diseases. We explored lipid alterations associated with brain diseases, paying attention to organ-specific characteristics and the functions of brain lipids. As the recent advances in brain lipidomics would have been impossible without advances in analytical techniques, we provide up-to-date information on mass spectrometric approaches and integrative analysis with other omic approaches. Last, we present the potential applications of lipidomics combined with artificial intelligence techniques and interdisciplinary collaborative research for treating brain diseases with clinical heterogeneities. This review article explores lipid alterations in brain diseases and provides insight for future brain lipidomic research.
AbstractList Lipids are crucial components of cellular function owing to their role in membrane formation, intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid dysregulations have been associated with the etiology and progression of neurodegeneration and other neurological pathologies. Hence, brain lipids are emerging as important potential targets for the early diagnosis and prognosis of neurological diseases. This review aims to highlight the significance and usefulness of lipidomics in diagnosing and treating brain diseases. We explored lipid alterations associated with brain diseases, paying attention to organ-specific characteristics and the functions of brain lipids. As the recent advances in brain lipidomics would have been impossible without advances in analytical techniques, we provide up-to-date information on mass spectrometric approaches and integrative analysis with other omic approaches. Last, we present the potential applications of lipidomics combined with artificial intelligence techniques and interdisciplinary collaborative research for treating brain diseases with clinical heterogeneities. This review article explores lipid alterations in brain diseases and provides insight for future brain lipidomic research.
Lipids are crucial components of cellular function owing to their role in membrane formation, intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid dysregulations have been associated with the etiology and progression of neurodegeneration and other neurological pathologies. Hence, brain lipids are emerging as important potential targets for the early diagnosis and prognosis of neurological diseases. This review aims to highlight the significance and usefulness of lipidomics in diagnosing and treating brain diseases. We explored lipid alterations associated with brain diseases, paying attention to organ-specific characteristics and the functions of brain lipids. As the recent advances in brain lipidomics would have been impossible without advances in analytical techniques, we provide up-to-date information on mass spectrometric approaches and integrative analysis with other omic approaches. Last, we present the potential applications of lipidomics combined with artificial intelligence techniques and interdisciplinary collaborative research for treating brain diseases with clinical heterogeneities.Lipids are crucial components of cellular function owing to their role in membrane formation, intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid dysregulations have been associated with the etiology and progression of neurodegeneration and other neurological pathologies. Hence, brain lipids are emerging as important potential targets for the early diagnosis and prognosis of neurological diseases. This review aims to highlight the significance and usefulness of lipidomics in diagnosing and treating brain diseases. We explored lipid alterations associated with brain diseases, paying attention to organ-specific characteristics and the functions of brain lipids. As the recent advances in brain lipidomics would have been impossible without advances in analytical techniques, we provide up-to-date information on mass spectrometric approaches and integrative analysis with other omic approaches. Last, we present the potential applications of lipidomics combined with artificial intelligence techniques and interdisciplinary collaborative research for treating brain diseases with clinical heterogeneities.
Lipids are crucial components of cellular function owing to their role in membrane formation, intercellular signaling, energy storage, and homeostasis maintenance. In the brain, lipid dysregulations have been associated with the etiology and progression of neurodegeneration and other neurological pathologies. Hence, brain lipids are emerging as important potential targets for the early diagnosis and prognosis of neurological diseases. This review aims to highlight the significance and usefulness of lipidomics in diagnosing and treating brain diseases. We explored lipid alterations associated with brain diseases, paying attention to organ-specific characteristics and the functions of brain lipids. As the recent advances in brain lipidomics would have been impossible without advances in analytical techniques, we provide up-to-date information on mass spectrometric approaches and integrative analysis with other omic approaches. Last, we present the potential applications of lipidomics combined with artificial intelligence techniques and interdisciplinary collaborative research for treating brain diseases with clinical heterogeneities.
Author Lee, Seulah
Cazenave-Gassiot, Amaury
Yoon, Jong Hyuk
Cho, Eunji
Wenk, Markus R.
Seo, Youngsuk
Shin, Yong-Seung
Jo, Yeon Suk
Suh, Pann-Ghill
An, Hyun Joo
Moon, Myeong Hee
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  surname: Jo
  fullname: Jo, Yeon Suk
  organization: Neurodegenerative Diseases Research Group, Korea Brain Research Institute, Daegu 41062, Republic of Korea., Department of Brain Sciences, Daegu-Gyeongbuk Institute of Science and Technology (DGIST), Daegu 42988, Republic of Korea
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  orcidid: 0000-0002-9589-3643
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  organization: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore., Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore 119077, Singapore
– sequence: 7
  givenname: Yong-Seung
  orcidid: 0000-0002-2738-6201
  surname: Shin
  fullname: Shin, Yong-Seung
  organization: Laboratory Solutions Sales, Agilent Technologies Korea Ltd., Seoul, 06621, Republic of Korea
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  orcidid: 0000-0002-5454-2601
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  givenname: Hyun Joo
  orcidid: 0000-0001-5847-7483
  surname: An
  fullname: An, Hyun Joo
  organization: Graduate School of Analytical Science and Technology, Chungnam National University, Daejeon 34134, Republic of Korea
– sequence: 10
  givenname: Markus R.
  orcidid: 0000-0001-5447-7881
  surname: Wenk
  fullname: Wenk, Markus R.
  organization: Department of Biochemistry, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119077, Singapore., Singapore Lipidomics Incubator (SLING), Life Sciences Institute, National University of Singapore, Singapore 119077, Singapore
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  orcidid: 0000-0002-9811-756X
  surname: Suh
  fullname: Suh, Pann-Ghill
  organization: Korea Brain Research Institute, Daegu 41062, Republic of Korea
BackLink https://www.ncbi.nlm.nih.gov/pubmed/36112688$$D View this record in MEDLINE/PubMed
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Cites_doi 10.1002/mds.26797
10.1021/ac802395d
10.1016/j.jnutbio.2010.07.005
10.1186/s13024-019-0333-5
10.2337/db13-1531
10.1093/hmg/ddv262
10.1152/physrev.00003.2009
10.1016/j.bbamem.2009.08.016
10.1016/j.celrep.2021.109898
10.1194/jlr.D083261
10.1016/j.tibs.2016.08.010
10.1093/nar/gkaa1074
10.1038/s41380-018-0200-8
10.3390/ijms22094820
10.1523/JNEUROSCI.23-13-05928.2003
10.1111/jnc.14603
10.1007/s12035-019-01775-7
10.1073/pnas.2016710117
10.3389/fnana.2015.00091
10.1007/978-1-4020-8831-5_9
10.1016/j.neurobiolaging.2008.05.010
10.1101/2021.05.10.21255052
10.1016/S0009-3084(00)00128-6
10.1203/00006450-200205000-00005
10.1002/brb3.517
10.1083/jcb.200207113
10.1194/jlr.M400486-JLR200
10.1021/acs.jproteome.5b00076
10.1007/s11745-002-0947-6
10.1007/978-1-4939-7704-8_17
10.1016/j.ab.2017.01.010
10.1021/acs.jproteome.6b00848
10.1007/s12035-018-1448-3
10.1007/s00216-010-4273-8
10.3390/cells8111323
10.1007/s11306-012-0456-y
10.1016/j.neurobiolaging.2016.08.027
10.1038/ncb1313
10.1126/scisignal.aaw2964
10.1039/D1AN00449B
10.1177/1533317514539724
10.1186/s40035-020-00215-0
10.1007/BF00966592
10.1038/s41467-021-23840-3
10.1016/j.neurobiolaging.2007.07.024
10.1016/j.psychres.2018.12.008
10.1096/fasebj.5.7.1901288
10.1002/cncr.23741
10.1016/S0092-8674(00)80513-9
10.1186/s13059-017-1215-1
10.3390/ijms14011310
10.1002/mds.28472
10.1038/d41586-018-05718-5
10.1021/acs.jproteome.0c00082
10.1016/j.ebiom.2019.08.051
10.5702/massspectrometry.A0004
10.1016/j.neuron.2015.01.003
10.1016/S0969-9961(02)00009-8
10.1021/acs.analchem.0c05017
10.1093/brain/awq376
10.1371/journal.pone.0017299
10.1021/acs.analchem.7b04836
10.1007/s13238-014-0131-3
10.1007/s00216-020-02446-6
10.1073/pnas.0801775105
10.1038/s41467-019-08897-5
10.1016/j.jinf.2015.02.011
10.1073/pnas.1523356113
10.1073/pnas.1604645113
10.1016/j.nbd.2007.10.005
10.1073/pnas.2012171118
10.1111/j.1460-9568.2008.06310.x
10.3390/ijms21093301
10.1021/acs.analchem.5b04491
10.1194/jlr.R800049-JLR200
10.1007/978-1-0716-0864-7_20
10.1074/jbc.M300466200
10.3389/fmolb.2015.00054
10.3390/ijms22115793
10.1016/j.neulet.2020.135455
10.3389/fphys.2021.645646
10.1046/j.1471-4159.2001.00332.x
10.1007/s11306-016-1093-7
10.1073/pnas.1307224110
10.1016/j.neurobiolaging.2014.02.005
10.1016/j.plipres.2013.10.002
10.1016/j.aca.2020.09.051
10.1038/sj.mp.4001509
10.1016/j.nbd.2007.05.003
10.1038/s41591-020-0815-6
10.1385/JMN:16:2-3:195
10.1038/nrn2233
10.1111/pcn.13194
10.1016/j.jalz.2017.01.008
10.2217/17460875.2.4.403
10.1016/j.addr.2020.04.009
10.1096/fj.10-168633
10.1111/j.1440-1819.2010.02132.x
10.1016/j.neubiorev.2016.06.002
10.1016/j.devcel.2016.09.030
10.1016/bs.irn.2015.05.008
10.3390/cells8010027
10.1016/j.tig.2018.02.007
10.1038/nrn3012
10.3389/fnsyn.2021.618391
10.1074/jbc.M108414200
10.3389/fcell.2020.615856
10.5607/en.2019.28.5.554
10.1002/mrm.1127
10.1186/s13024-020-00391-7
10.1016/j.jchromb.2009.03.002
10.1016/j.yclnex.2018.05.001
10.1016/j.csbj.2020.06.001
10.1016/j.neuron.2014.02.027
10.1016/S1474-4422(18)30499-X
10.1089/ars.2019.7763
10.1111/j.1471-4159.2007.04715.x
10.1016/j.yfrne.2021.100899
10.1016/j.arr.2021.101346
10.1186/s12944-019-0965-z
10.1038/s41514-021-00064-9
10.1186/s13195-019-0558-0
10.1021/jasms.1c00251
10.1038/s41598-020-76973-8
10.1371/journal.pmed.1002482
10.3389/fnmol.2017.00382
10.1098/rsob.170069
10.1038/s41598-017-05709-y
10.1155/2013/239854
10.1016/j.celrep.2020.108132
10.1016/j.ijdevneu.2004.07.004
10.3389/fnmol.2018.00010
10.1093/nar/gkab419
10.1093/nar/gkv1042
10.1159/000452256
10.1038/cdd.2014.30
10.1016/j.jpsychires.2017.08.009
10.1203/01.PDR.0000054654.73826.AC
10.1037/h0087710
10.1073/pnas.0604954103
10.1038/nrn3820
10.1016/j.plipres.2022.101165
10.3389/fnins.2019.00328
10.1186/alzrt135
10.1007/s00216-019-02241-y
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References e_1_3_2_28_2
e_1_3_2_20_2
e_1_3_2_43_2
e_1_3_2_62_2
e_1_3_2_85_2
e_1_3_2_24_2
e_1_3_2_47_2
e_1_3_2_66_2
e_1_3_2_89_2
e_1_3_2_100_2
e_1_3_2_123_2
e_1_3_2_146_2
e_1_3_2_104_2
e_1_3_2_142_2
Vance J. E. (e_1_3_2_147_2) 2012; 5
e_1_3_2_81_2
e_1_3_2_127_2
e_1_3_2_108_2
e_1_3_2_7_2
e_1_3_2_39_2
e_1_3_2_54_2
e_1_3_2_31_2
e_1_3_2_73_2
e_1_3_2_12_2
e_1_3_2_58_2
e_1_3_2_96_2
e_1_3_2_3_2
e_1_3_2_35_2
e_1_3_2_77_2
e_1_3_2_112_2
e_1_3_2_135_2
e_1_3_2_92_2
e_1_3_2_131_2
e_1_3_2_50_2
e_1_3_2_116_2
e_1_3_2_139_2
e_1_3_2_48_2
e_1_3_2_29_2
e_1_3_2_40_2
e_1_3_2_86_2
e_1_3_2_21_2
e_1_3_2_63_2
e_1_3_2_44_2
e_1_3_2_25_2
e_1_3_2_67_2
e_1_3_2_145_2
Jiang T. (e_1_3_2_16_2) 2014; 2
e_1_3_2_126_2
Cheng Y. (e_1_3_2_36_2) 2019; 11
e_1_3_2_82_2
e_1_3_2_103_2
e_1_3_2_141_2
e_1_3_2_122_2
e_1_3_2_149_2
e_1_3_2_107_2
e_1_3_2_17_2
e_1_3_2_59_2
e_1_3_2_6_2
e_1_3_2_32_2
e_1_3_2_51_2
e_1_3_2_74_2
Fernández-Irigoyen J. (e_1_3_2_33_2) 2021; 9
e_1_3_2_13_2
e_1_3_2_55_2
e_1_3_2_78_2
e_1_3_2_97_2
e_1_3_2_2_2
e_1_3_2_134_2
e_1_3_2_93_2
e_1_3_2_130_2
e_1_3_2_70_2
e_1_3_2_111_2
e_1_3_2_153_2
e_1_3_2_138_2
e_1_3_2_119_2
e_1_3_2_26_2
e_1_3_2_49_2
e_1_3_2_41_2
e_1_3_2_64_2
e_1_3_2_87_2
e_1_3_2_151_2
e_1_3_2_22_2
e_1_3_2_45_2
e_1_3_2_68_2
e_1_3_2_125_2
e_1_3_2_148_2
e_1_3_2_60_2
e_1_3_2_83_2
e_1_3_2_102_2
e_1_3_2_121_2
e_1_3_2_144_2
e_1_3_2_129_2
e_1_3_2_9_2
e_1_3_2_37_2
e_1_3_2_18_2
e_1_3_2_75_2
e_1_3_2_140_2
e_1_3_2_10_2
e_1_3_2_52_2
e_1_3_2_5_2
e_1_3_2_79_2
e_1_3_2_14_2
e_1_3_2_56_2
e_1_3_2_98_2
e_1_3_2_114_2
e_1_3_2_137_2
e_1_3_2_94_2
e_1_3_2_71_2
e_1_3_2_110_2
e_1_3_2_133_2
e_1_3_2_152_2
e_1_3_2_90_2
e_1_3_2_118_2
e_1_3_2_27_2
e_1_3_2_150_2
e_1_3_2_65_2
e_1_3_2_42_2
e_1_3_2_84_2
e_1_3_2_23_2
e_1_3_2_69_2
e_1_3_2_46_2
e_1_3_2_88_2
e_1_3_2_124_2
e_1_3_2_61_2
e_1_3_2_120_2
e_1_3_2_80_2
e_1_3_2_101_2
e_1_3_2_143_2
e_1_3_2_109_2
e_1_3_2_105_2
e_1_3_2_128_2
e_1_3_2_15_2
e_1_3_2_38_2
e_1_3_2_8_2
e_1_3_2_19_2
e_1_3_2_30_2
e_1_3_2_53_2
e_1_3_2_76_2
e_1_3_2_99_2
e_1_3_2_11_2
e_1_3_2_34_2
e_1_3_2_57_2
e_1_3_2_95_2
Cao W. (e_1_3_2_115_2) 2020; 11
e_1_3_2_4_2
e_1_3_2_91_2
e_1_3_2_113_2
e_1_3_2_136_2
e_1_3_2_72_2
Correia B. S. B. (e_1_3_2_106_2) 2021; 9
e_1_3_2_132_2
e_1_3_2_117_2
References_xml – ident: e_1_3_2_93_2
  doi: 10.1002/mds.26797
– ident: e_1_3_2_116_2
  doi: 10.1021/ac802395d
– volume: 2
  start-page: 125
  year: 2014
  ident: e_1_3_2_16_2
  article-title: Application of next-generation sequencing technologies in Neurology
  publication-title: Ann. Transl. Med.
– ident: e_1_3_2_42_2
  doi: 10.1016/j.jnutbio.2010.07.005
– ident: e_1_3_2_7_2
  doi: 10.1186/s13024-019-0333-5
– ident: e_1_3_2_26_2
  doi: 10.2337/db13-1531
– ident: e_1_3_2_88_2
  doi: 10.1093/hmg/ddv262
– ident: e_1_3_2_24_2
  doi: 10.1152/physrev.00003.2009
– ident: e_1_3_2_62_2
  doi: 10.1016/j.bbamem.2009.08.016
– ident: e_1_3_2_143_2
  doi: 10.1016/j.celrep.2021.109898
– ident: e_1_3_2_118_2
  doi: 10.1194/jlr.D083261
– ident: e_1_3_2_127_2
  doi: 10.1016/j.tibs.2016.08.010
– ident: e_1_3_2_15_2
  doi: 10.1093/nar/gkaa1074
– ident: e_1_3_2_109_2
  doi: 10.1038/s41380-018-0200-8
– ident: e_1_3_2_12_2
  doi: 10.3390/ijms22094820
– ident: e_1_3_2_50_2
  doi: 10.1523/JNEUROSCI.23-13-05928.2003
– ident: e_1_3_2_19_2
  doi: 10.1111/jnc.14603
– ident: e_1_3_2_108_2
  doi: 10.1007/s12035-019-01775-7
– ident: e_1_3_2_8_2
  doi: 10.1073/pnas.2016710117
– ident: e_1_3_2_92_2
  doi: 10.3389/fnana.2015.00091
– ident: e_1_3_2_25_2
  doi: 10.1007/978-1-4020-8831-5_9
– ident: e_1_3_2_81_2
  doi: 10.1016/j.neurobiolaging.2008.05.010
– ident: e_1_3_2_149_2
  doi: 10.1101/2021.05.10.21255052
– ident: e_1_3_2_55_2
  doi: 10.1016/S0009-3084(00)00128-6
– ident: e_1_3_2_110_2
  doi: 10.1203/00006450-200205000-00005
– ident: e_1_3_2_124_2
  doi: 10.1002/brb3.517
– ident: e_1_3_2_76_2
  doi: 10.1083/jcb.200207113
– ident: e_1_3_2_74_2
  doi: 10.1194/jlr.M400486-JLR200
– ident: e_1_3_2_123_2
  doi: 10.1021/acs.jproteome.5b00076
– ident: e_1_3_2_48_2
  doi: 10.1007/s11745-002-0947-6
– ident: e_1_3_2_113_2
– ident: e_1_3_2_128_2
  doi: 10.1007/978-1-4939-7704-8_17
– ident: e_1_3_2_132_2
  doi: 10.1016/j.ab.2017.01.010
– ident: e_1_3_2_130_2
  doi: 10.1021/acs.jproteome.6b00848
– ident: e_1_3_2_146_2
  doi: 10.1007/s12035-018-1448-3
– ident: e_1_3_2_34_2
  doi: 10.1007/s00216-010-4273-8
– ident: e_1_3_2_65_2
  doi: 10.3390/cells8111323
– ident: e_1_3_2_152_2
  doi: 10.1007/s11306-012-0456-y
– ident: e_1_3_2_153_2
  doi: 10.1016/j.neurobiolaging.2016.08.027
– ident: e_1_3_2_79_2
  doi: 10.1038/ncb1313
– ident: e_1_3_2_134_2
  doi: 10.1126/scisignal.aaw2964
– ident: e_1_3_2_121_2
  doi: 10.1039/D1AN00449B
– ident: e_1_3_2_5_2
  doi: 10.1177/1533317514539724
– volume: 11
  start-page: 1
  year: 2020
  ident: e_1_3_2_115_2
  article-title: Large-scale lipid analysis with C= C location and sn-position isomer resolving power
  publication-title: Nat. Commun.
– ident: e_1_3_2_139_2
  doi: 10.1186/s40035-020-00215-0
– ident: e_1_3_2_111_2
  doi: 10.1007/BF00966592
– volume: 9
  start-page: 235
  year: 2021
  ident: e_1_3_2_106_2
  article-title: Effects of psychostimulants and antipsychotics on serum lipids in an animal model for schizophrenia
  publication-title: Biomedicine
– ident: e_1_3_2_45_2
  doi: 10.1038/s41467-021-23840-3
– ident: e_1_3_2_75_2
  doi: 10.1016/j.neurobiolaging.2007.07.024
– ident: e_1_3_2_69_2
  doi: 10.1016/j.psychres.2018.12.008
– ident: e_1_3_2_57_2
  doi: 10.1096/fasebj.5.7.1901288
– ident: e_1_3_2_3_2
  doi: 10.1002/cncr.23741
– ident: e_1_3_2_101_2
  doi: 10.1016/S0092-8674(00)80513-9
– ident: e_1_3_2_9_2
  doi: 10.1186/s13059-017-1215-1
– ident: e_1_3_2_56_2
  doi: 10.3390/ijms14011310
– ident: e_1_3_2_141_2
  doi: 10.1002/mds.28472
– ident: e_1_3_2_4_2
  doi: 10.1038/d41586-018-05718-5
– ident: e_1_3_2_135_2
  doi: 10.1021/acs.jproteome.0c00082
– ident: e_1_3_2_138_2
  doi: 10.1016/j.ebiom.2019.08.051
– ident: e_1_3_2_125_2
  doi: 10.5702/massspectrometry.A0004
– ident: e_1_3_2_151_2
  doi: 10.1016/j.neuron.2015.01.003
– ident: e_1_3_2_11_2
  doi: 10.1016/S0969-9961(02)00009-8
– ident: e_1_3_2_122_2
  doi: 10.1021/acs.analchem.0c05017
– ident: e_1_3_2_54_2
  doi: 10.1093/brain/awq376
– ident: e_1_3_2_70_2
  doi: 10.1371/journal.pone.0017299
– ident: e_1_3_2_20_2
  doi: 10.1021/acs.analchem.7b04836
– ident: e_1_3_2_51_2
  doi: 10.1007/s13238-014-0131-3
– ident: e_1_3_2_119_2
  doi: 10.1007/s00216-020-02446-6
– ident: e_1_3_2_10_2
  doi: 10.1073/pnas.0801775105
– ident: e_1_3_2_133_2
  doi: 10.1038/s41467-019-08897-5
– ident: e_1_3_2_32_2
  doi: 10.1016/j.jinf.2015.02.011
– ident: e_1_3_2_120_2
  doi: 10.1073/pnas.1523356113
– ident: e_1_3_2_97_2
  doi: 10.1073/pnas.1604645113
– ident: e_1_3_2_78_2
  doi: 10.1016/j.nbd.2007.10.005
– ident: e_1_3_2_96_2
  doi: 10.1073/pnas.2012171118
– ident: e_1_3_2_103_2
  doi: 10.1111/j.1460-9568.2008.06310.x
– volume: 11
  start-page: 238
  year: 2019
  ident: e_1_3_2_36_2
  article-title: How does the brain remove its waste metabolites from within?
  publication-title: Int. J. Physiol. Pathophysiol. Pharmacol.
– ident: e_1_3_2_91_2
  doi: 10.3390/ijms21093301
– ident: e_1_3_2_129_2
  doi: 10.1021/acs.analchem.5b04491
– ident: e_1_3_2_47_2
  doi: 10.1194/jlr.R800049-JLR200
– ident: e_1_3_2_114_2
  doi: 10.1007/978-1-0716-0864-7_20
– ident: e_1_3_2_82_2
  doi: 10.1074/jbc.M300466200
– ident: e_1_3_2_6_2
  doi: 10.3389/fmolb.2015.00054
– ident: e_1_3_2_49_2
  doi: 10.3390/ijms22115793
– ident: e_1_3_2_38_2
  doi: 10.1016/j.neulet.2020.135455
– ident: e_1_3_2_43_2
  doi: 10.3389/fphys.2021.645646
– ident: e_1_3_2_87_2
  doi: 10.1046/j.1471-4159.2001.00332.x
– ident: e_1_3_2_30_2
  doi: 10.1007/s11306-016-1093-7
– ident: e_1_3_2_66_2
  doi: 10.1073/pnas.1307224110
– ident: e_1_3_2_72_2
  doi: 10.1016/j.neurobiolaging.2014.02.005
– ident: e_1_3_2_89_2
  doi: 10.1016/j.plipres.2013.10.002
– ident: e_1_3_2_142_2
  doi: 10.1016/j.aca.2020.09.051
– ident: e_1_3_2_83_2
  doi: 10.1038/sj.mp.4001509
– ident: e_1_3_2_102_2
  doi: 10.1016/j.nbd.2007.05.003
– ident: e_1_3_2_14_2
  doi: 10.1038/s41591-020-0815-6
– ident: e_1_3_2_44_2
  doi: 10.1385/JMN:16:2-3:195
– volume: 9
  start-page: 491
  year: 2021
  ident: e_1_3_2_33_2
  article-title: Alteration in the cerebrospinal fluid lipidome in Parkinson’s disease: A post-mortem pilot study
  publication-title: Biomedicine
– ident: e_1_3_2_61_2
  doi: 10.1038/nrn2233
– ident: e_1_3_2_131_2
  doi: 10.1111/pcn.13194
– ident: e_1_3_2_29_2
  doi: 10.1016/j.jalz.2017.01.008
– ident: e_1_3_2_67_2
  doi: 10.2217/17460875.2.4.403
– ident: e_1_3_2_63_2
  doi: 10.1016/j.addr.2020.04.009
– ident: e_1_3_2_77_2
  doi: 10.1096/fj.10-168633
– ident: e_1_3_2_35_2
  doi: 10.1111/j.1440-1819.2010.02132.x
– ident: e_1_3_2_145_2
  doi: 10.1016/j.neubiorev.2016.06.002
– ident: e_1_3_2_23_2
  doi: 10.1016/j.devcel.2016.09.030
– ident: e_1_3_2_28_2
  doi: 10.1016/bs.irn.2015.05.008
– ident: e_1_3_2_90_2
  doi: 10.3390/cells8010027
– ident: e_1_3_2_18_2
  doi: 10.1016/j.tig.2018.02.007
– ident: e_1_3_2_80_2
  doi: 10.1038/nrn3012
– ident: e_1_3_2_100_2
  doi: 10.3389/fnsyn.2021.618391
– ident: e_1_3_2_98_2
  doi: 10.1074/jbc.M108414200
– ident: e_1_3_2_22_2
  doi: 10.3389/fcell.2020.615856
– ident: e_1_3_2_39_2
  doi: 10.5607/en.2019.28.5.554
– ident: e_1_3_2_112_2
  doi: 10.1002/mrm.1127
– ident: e_1_3_2_71_2
  doi: 10.1186/s13024-020-00391-7
– ident: e_1_3_2_150_2
  doi: 10.1016/j.jchromb.2009.03.002
– ident: e_1_3_2_148_2
  doi: 10.1016/j.yclnex.2018.05.001
– ident: e_1_3_2_31_2
  doi: 10.1016/j.csbj.2020.06.001
– ident: e_1_3_2_84_2
  doi: 10.1016/j.neuron.2014.02.027
– ident: e_1_3_2_2_2
  doi: 10.1016/S1474-4422(18)30499-X
– ident: e_1_3_2_27_2
  doi: 10.1089/ars.2019.7763
– ident: e_1_3_2_52_2
  doi: 10.1111/j.1471-4159.2007.04715.x
– ident: e_1_3_2_144_2
  doi: 10.1016/j.yfrne.2021.100899
– ident: e_1_3_2_17_2
  doi: 10.1016/j.arr.2021.101346
– ident: e_1_3_2_59_2
  doi: 10.1186/s12944-019-0965-z
– volume: 5
  start-page: 746
  year: 2012
  ident: e_1_3_2_147_2
  article-title: Dysregulation of cholesterol balance in the brain: Contribution to neurodegenerative diseases
  publication-title: Dis. Model. Mech.
– ident: e_1_3_2_53_2
  doi: 10.1038/s41514-021-00064-9
– ident: e_1_3_2_140_2
  doi: 10.1186/s13195-019-0558-0
– ident: e_1_3_2_117_2
  doi: 10.1021/jasms.1c00251
– ident: e_1_3_2_68_2
  doi: 10.1038/s41598-020-76973-8
– ident: e_1_3_2_37_2
  doi: 10.1371/journal.pmed.1002482
– ident: e_1_3_2_40_2
  doi: 10.3389/fnmol.2017.00382
– ident: e_1_3_2_60_2
  doi: 10.1098/rsob.170069
– ident: e_1_3_2_104_2
  doi: 10.1038/s41598-017-05709-y
– ident: e_1_3_2_94_2
  doi: 10.1155/2013/239854
– ident: e_1_3_2_126_2
  doi: 10.1016/j.celrep.2020.108132
– ident: e_1_3_2_86_2
  doi: 10.1016/j.ijdevneu.2004.07.004
– ident: e_1_3_2_41_2
  doi: 10.3389/fnmol.2018.00010
– ident: e_1_3_2_136_2
  doi: 10.1093/nar/gkab419
– ident: e_1_3_2_137_2
  doi: 10.1093/nar/gkv1042
– ident: e_1_3_2_13_2
  doi: 10.1159/000452256
– ident: e_1_3_2_99_2
  doi: 10.1038/cdd.2014.30
– ident: e_1_3_2_107_2
  doi: 10.1016/j.jpsychires.2017.08.009
– ident: e_1_3_2_64_2
  doi: 10.1203/01.PDR.0000054654.73826.AC
– ident: e_1_3_2_105_2
  doi: 10.1037/h0087710
– ident: e_1_3_2_85_2
  doi: 10.1073/pnas.0604954103
– ident: e_1_3_2_46_2
  doi: 10.1038/nrn3820
– ident: e_1_3_2_58_2
  doi: 10.1016/j.plipres.2022.101165
– ident: e_1_3_2_95_2
  doi: 10.3389/fnins.2019.00328
– ident: e_1_3_2_73_2
  doi: 10.1186/alzrt135
– ident: e_1_3_2_21_2
  doi: 10.1007/s00216-019-02241-y
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Snippet Lipids are crucial components of cellular function owing to their role in membrane formation, intercellular signaling, energy storage, and homeostasis...
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SubjectTerms Artificial Intelligence
Brain
Brain Diseases - diagnosis
Brain Diseases - etiology
Developmental Neuroscience
Humans
Lipid Metabolism
Lipidomics
Lipids - chemistry
Network Science
Neuroscience
Review
SciAdv reviews
Title Brain lipidomics: From functional landscape to clinical significance
URI https://www.ncbi.nlm.nih.gov/pubmed/36112688
https://www.proquest.com/docview/2715446094
https://pubmed.ncbi.nlm.nih.gov/PMC9481132
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