A Copeptin-Based Approach in the Diagnosis of Diabetes Insipidus

• Published in: The New England journal of medicine Vol. 379; no. 5; pp. 428 - 439
• Main Authors: Fenske, Wiebke, Refardt, Julie, Chifu, Irina, Schnyder, Ingeborg, Winzeler, Bettina, Drummond, Juliana, Ribeiro-Oliveira, Antônio, Drescher, Tilman, Bilz, Stefan, Vogt, Deborah R, Malzahn, Uwe, Kroiss, Matthias, Christ, Emanuel, Henzen, Christoph, Fischli, Stefan, Tönjes, Anke, Mueller, Beat, Schopohl, Jochen, Flitsch, Jörg, Brabant, Georg, Fassnacht, Martin, Christ-Crain, Mirjam
• Format: Journal Article
• Language: English
• Published: United States Massachusetts Medical Society 02.08.2018
• Subjects: Accuracy; Adult; Argipressin; Clinical medicine; Clinical trials; Confidence intervals; Deamino Arginine Vasopressin - administration & dosage; Deamino Arginine Vasopressin - adverse effects; Desmopressin; Diabetes; Diabetes insipidus; Diabetes Insipidus - blood; Diabetes Insipidus - complications; Diabetes Insipidus - diagnosis; Diabetes Insipidus - physiopathology; Diagnosis; Diagnosis, Differential; Endocrinology; Female; Glycopeptides - blood; Hospitals; Humans; Hyponatremia; Hyponatremia - chemically induced; Laboratories; Male; Medical diagnosis; Metabolism; Middle Aged; Nephrology; NMR; Nuclear magnetic resonance; Osmolar Concentration; Osmosis; Patients; Plasma; Polydipsia; Polydipsia - blood; Polydipsia - complications; Polydipsia - diagnosis; Polyuria; Polyuria - etiology; ROC Curve; Saline Solution, Hypertonic - administration & dosage; Sensitivity and Specificity; Sodium; Urine; Urine - chemistry; Vasopressin; Water Deprivation - physiology; Brazil; Switzerland; Germany
• ISSN: 0028-4793; 1533-4406
• DOI: 10.1056/NEJMoa1803760

This study compared the indirect water-deprivation test with direct detection of plasma copeptin, a precursor of arginine vasopressin, in patients with hypotonic polyuria. Direct measurement of hypertonic saline–stimulated plasma copeptin had higher diagnostic accuracy.