Laparoscopic presacral neurolysis for endometriosis‐related pelvic pain

• Published in: Human reproduction (Oxford) Vol. 18; no. 3; pp. 588 - 592
• Main Authors: Soysal, Mehmet Emin, Soysal, Seyide, Gurses, Ercan, Ozer, Suzan
• Format: Journal Article
• Language: English
• Published: Oxford Oxford University Press 01.03.2003; Oxford Publishing Limited (England)
• Subjects: Adult; Analgesics - administration & dosage; Anti-Inflammatory Agents, Non-Steroidal - administration & dosage; Biological and medical sciences; Coitus; Constipation - etiology; Endometriosis; Endometriosis - complications; Endometriosis - diagnostic imaging; Endometriosis - physiopathology; Endometriosis - surgery; Feasibility Studies; Female; Fluoroscopy; Humans; Key words: endometriosis/neurolysis/pelvic pain/presacral neurectomy; Laparoscopy; Medical sciences; Menstruation; Naproxen - administration & dosage; Naproxen - adverse effects; Pelvic Pain - drug therapy; Pelvic Pain - etiology; Phenol - therapeutic use; Prospective Studies; Sacrococcygeal Region; Severity of Illness Index; Surgery (general aspects). Transplantations, organ and tissue grafts. Graft diseases; Surgery of the genital tract and mammary gland; Sympathectomy, Chemical - adverse effects; Sympathectomy, Chemical - methods; Treatment Outcome; endometriosis/neurolysis/pelvic pain/presacral neurectomy; Human; Sympathectomy; Treatment efficiency; Endometriosis; Hypogastric nerve; Laparoscopy; Presacral; Pelvic pain; Female genital diseases; Neurolysis; Technology; Surgery; Uterine diseases; Female; Technique
• ISSN: 0268-1161; 1460-2350; 1460-2350
• DOI: 10.1093/humrep/deg127

BACKGROUND: Some patients with endometriosis are candidates for sympathectomy of the superior hypogastric plexus. The objective of this paper is to describe our technique of laparoscopic presacral neurolysis for sympathectomy and to report 1 year results of the first 15 cases. METHODS: To achieve this objective in a prospective observational study of 1 year follow‐up; we performed laparoscopic presacral chemical neurolysis with phenol in 15 patients with pelvic pain and minimal–moderate endometriosis. The main outcome measures were: the impact of treatment on pelvic symptom resolution, non‐opioid analgesic consumption during menses, sexual performance and observed complications and side effects during 1 year follow‐up. RESULTS: We noted a significant reduction in total pelvic symptom score as compared with baseline mean (SD) of 9.04 (1.2). The mean difference [95% confidence interval (CI)] of reduction was 5.7 (4.9–6.5), 5.8 (5.0–6.6) and 5.8 (4.9–6.6) from the baseline at the 3rd, 6th and 12th postoperative month (P < 0.001). We observed a significant improvement in Sabbatberg Sexual Rating Scale as compared with baseline mean (SD) of 30.9 (4.3). The mean difference (95% CI) of increase was 33.4 (30.3–36.4), 33.2 (30.1–36.2) and 33.2 (30.1–36.3) from the baseline at the 3rd, 6th and 12th postoperative month. We observed a significant reduction in analgesic consumption during menses in terms of total naproxen sodium tablets as compared with baseline mean (SD) of 8.9 (1.1). The mean difference (95% CI) of reduction in the total number of naproxen sodium 250 mg tablets was 6.5 (5.5–7.5), 6.7 (5.7–7.7) and 6.6 (5.6–7.6) from the baseline at the 3rd, 6th and 12th postoperative month. The most common side effect was constipation. CONCLUSION: Laparoscopic presacral neurolysis is feasible and simple. More data is needed to support its efficacy and safety.