The presumed central nervous system effects of rocuronium in a neonate and its reversal with sugammadex

Summary We describe a 2‐day‐old male infant who received rocuronium as part of general anesthesia for a tracheal esophageal fistula repair. Postoperatively, he had prolonged central and peripheral neuromuscular blockade despite cessation of the rocuronium infusion several hours previously. This case...

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Published inPediatric anesthesia Vol. 26; no. 1; pp. 109 - 111
Main Authors Langley, Ross J., McFadzean, Jillian, McCormack, Jon, Lerman, Jerrold
Format Journal Article
LanguageEnglish
Published France Wiley Subscription Services, Inc 01.01.2016
Subjects
Androstanols - pharmacology
blood–brain barrier
Central Nervous System - drug effects
gamma-Cyclodextrins - administration & dosage
Humans
Infant, Newborn
Male
neonate
Nervous system
Neuromuscular Blockade - methods
Neuromuscular Nondepolarizing Agents - pharmacology
rocuronium
sugammadex
blood-brain barrier
rocuronium
neonate
sugammadex
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Summary:Summary We describe a 2‐day‐old male infant who received rocuronium as part of general anesthesia for a tracheal esophageal fistula repair. Postoperatively, he had prolonged central and peripheral neuromuscular blockade despite cessation of the rocuronium infusion several hours previously. This case discusses the presumed central nervous system effects of rocuronium in a neonate and its effective reversal with sugammadex.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
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ObjectType-Report-1
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ISSN:1155-5645
1460-9592
DOI:10.1111/pan.12789