Designing a blueprint for next‐generation stem cell bioprocessing development

• Published in: Biotechnology and bioengineering Vol. 117; no. 3; pp. 832 - 843
• Main Authors: Kim, Mee‐Hae, Kino‐oka, Masahiro
• Format: Journal Article
• Language: English
• Published: United States Wiley Subscription Services, Inc 01.03.2020
• Subjects: Bioengineering; Bioprocessing; bioprocessing blueprint; Bioreactors; Cell culture; Cell Culture Techniques; Cell Differentiation; Cells, Cultured; culture technologies and tools; Epigenesis, Genetic; Humans; Industrial applications; Landscape architecture; stem cell; Stem cells; Stem Cells - cytology; Stem Cells - metabolism; Waddington's epigenetic landscape; bioprocessing blueprint; culture technologies and tools; Waddington's epigenetic landscape; stem cell
• ISSN: 0006-3592; 1097-0290
• DOI: 10.1002/bit.27228

The creation of a blueprint for stem cell bioprocess development that it is easily readable and shareable among those involved in the construction of the bioprocess is a necessary step toward full‐fledged bioprocess integration. The blueprint provides the culturing tools and methodologies, designed to highlight knowledge gaps within biological sciences and bioengineering. This review highlights a blueprint for stem cell bioprocessing development using a landscape architecture approach that can aid the development of culture technologies and tools that satisfy the demands for stem cell‐derived products for use in clinical and industrial applications. This work is intended to provide insights to cell biologists, geneticists, bioengineers, and clinicians seeking knowledge outside of their field of expertise and fosters a leap from a reductionist approach to one, that is, globally integrated in stem cell bioprocessing. The creation of a blueprint for stem cell bioprocess development that it is easily readable and shareable among those involved in the construction of the bioprocess is a necessary step toward full‐fledged bioprocess integration.