Neonatal exposure to thymotropic gross murine leukemia virus induces virus-specific immunologic nonresponsiveness

• Published in: The Journal of experimental medicine Vol. 172; no. 6; pp. 1765 - 1775
• Main Authors: KOROSTOFF, J. M, NAKADA, M. T, FAAS, S. J, BLANK, K. J, GAULTON, G. N
• Format: Journal Article
• Language: English
• Published: New York, NY Rockefeller University Press 01.12.1990; The Rockefeller University Press
• Subjects: AKR murine leukemia virus - immunology; AKR murine leukemia virus - physiology; Animals; Animals, Newborn; Antibodies, Viral - analysis; Antibody Formation; Antigen-Antibody Complex - analysis; Biological and medical sciences; Cell Line; Fundamental and applied biological sciences. Psychology; Fundamental immunology; Hypersensitivity, Delayed; Immunity, Cellular; Immunobiology; Immunological tolerance; Immunosuppression; Leukemia, Experimental - immunology; Leukemia, Experimental - microbiology; Lymphocyte Culture Test, Mixed; Mice; Mice, Inbred BALB C; Reference Values; Thymus Gland - immunology; Viral Envelope Proteins - immunology; Virus Replication; Oncovirinae; Immunization; Induction; Rodentia; Retroviridae; Virus; Vertebrata; Mammalia; Mouse; Type C oncovirus; Newborn animal; Immune tolerance; Murine leukemia virus
• ISSN: 0022-1007; 1540-9538
• DOI: 10.1084/jem.172.6.1765

Neonatal exposure to Gross murine leukemia virus results in a profound inhibition of the virus-specific T and B cell responses of adult animals. Animals exposed to virus as neonates exhibit a marked depression in virus-specific T cell function as measured by the virtual absence of in vivo delayed type hypersensitivity responses and in vitro proliferative responses to virally infected stimulator cells. Further, serum obtained from neonatally treated mice failed to either immunoprecipitate viral proteins or neutralize virus in an in vitro plaque assay, suggesting the concurrent induction of a state of B cell hyporesponsiveness. The specificity of this effect at the levels of both T and B cells was demonstrated by the ability of neonatally treated mice to respond normally after adult challenge with either irrelevant reovirus or influenza virus. The replication of Gross virus within both stromal and lymphocytic compartments of the neonatal thymus suggests that thymic education plays a key role in the induction of immunologic nonresponsiveness to viruses.