Pioglitazone may accelerate disease course of slowly progressive type 1 diabetes
Background It has been reported that intervention with insulin in slowly progressive type 1 diabetic (SPIDDM) patients delays the progression to an insulin‐dependent state compared to that with sulfonylureas. However, the rate of progression to SPIDDM with the use of insulin‐sensitizing agents is un...
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Published in | Diabetes/metabolism research and reviews Vol. 27; no. 8; pp. 951 - 953 |
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Main Authors | , , , , , |
Format | Journal Article |
Language | English |
Published |
Chichester, UK
John Wiley & Sons, Ltd
01.11.2011
Wiley Subscription Services, Inc |
Subjects | |
Online Access | Get full text |
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Summary: | Background
It has been reported that intervention with insulin in slowly progressive type 1 diabetic (SPIDDM) patients delays the progression to an insulin‐dependent state compared to that with sulfonylureas. However, the rate of progression to SPIDDM with the use of insulin‐sensitizing agents is unknown. The aim of this study was to determine the effect of insulin‐sensitizing agents on SPIDDM patients.
Methods
The enrolled SPIDDM patients were randomly allocated to a pioglitazone or metformin group. When the haemoglobin A1C level was more than 8% on two consecutive occasions, the case was considered to reach the end point.
Results
By 4 years post‐intervention, all patients had reached the end point in the pioglitazone group, whereas only 20% of patients had reached the end point in the metformin group (p < 0.05).
Conclusions
Pioglitazone may accelerate the disease course of SPIDDM. Copyright © 2011 John Wiley & Sons, Ltd. |
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Bibliography: | istex:96A9DEEF4249EAAC33802E9756525C96AD2BD773 Supporting InformationSupporting InformationSupporting Information ark:/67375/WNG-LJ6FD7RX-K ArticleID:DMRR1235 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-News-1 ObjectType-Feature-3 content type line 23 |
ISSN: | 1520-7552 1520-7560 |
DOI: | 10.1002/dmrr.1235 |