Does Autophagy Mediate Cardiac Myocyte Death During Stress?

Although autophagy generally promotes survival of cardiac myocytes, it also promotes death of cardiac myocytes in some conditions. Here we describe how activation of autophagy leads to death of cardiac myocytes, introduce a novel concept of autosis, a unique form of cell death by autophagy, and disc...

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Bibliographic Details
Published inCirculation research Vol. 119; no. 8; pp. 893 - 895
Main Authors Nah, Jihoon, Fernández, Álvaro F, Kitsis, Richard N, Levine, Beth, Sadoshima, Junichi
Format Journal Article
LanguageEnglish
Published United States American Heart Association, Inc 30.09.2016
Subjects
Animals
Autophagy - physiology
Humans
Myocytes, Cardiac - metabolism
Myocytes, Cardiac - pathology
Oxidative Stress - physiology
myocytes, cardiac
autophagy
cardiomyopathies
heart
mitochondrial degradation
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Summary:Although autophagy generally promotes survival of cardiac myocytes, it also promotes death of cardiac myocytes in some conditions. Here we describe how activation of autophagy leads to death of cardiac myocytes, introduce a novel concept of autosis, a unique form of cell death by autophagy, and discuss the functional significance of autophagic cell death in cardiac myocytes.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:0009-7330
1524-4571
DOI:10.1161/CIRCRESAHA.116.309765