Influence of dielectric constant on sedimentation rate of concentrated suspensions of aluminum and magnesium hydroxides

Sedimentation of dilute pharmaceutical suspensions obeys Stokes's law, which assumes that there is no interaction between particles. The behavior of concentrated pharmaceutical suspensions is generally interpreted by use of modifications of Stokes's law that do not consider chemical intera...

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Bibliographic Details
Published inJournal of pharmaceutical sciences Vol. 81; no. 8; p. 787
Main Authors Alexander, K S, Dollimore, D, Tata, S S, Murthy, A S
Format Journal Article
LanguageEnglish
Published United States 01.08.1992
Subjects
Aluminum Hydroxide - chemistry
Chemical Phenomena
Chemistry, Pharmaceutical - methods
Chemistry, Physical
Electrochemistry
Kinetics
Magnesium Hydroxide - chemistry
Mathematical Computing
Suspensions
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Summary:Sedimentation of dilute pharmaceutical suspensions obeys Stokes's law, which assumes that there is no interaction between particles. The behavior of concentrated pharmaceutical suspensions is generally interpreted by use of modifications of Stokes's law that do not consider chemical interaction between particles. Properties of the medium itself, such as dielectric constant and surface tension, have not been included in the established equations. The present work shows that the dielectric constant of the medium has a distinct effect on the rate of sedimentation of the systems investigated.
ISSN:0022-3549
DOI:10.1002/jps.2600810813