AIDS Presenting as Granulomatous Amebic Encephalitis: PET and MR Imaging correlation

Granulomatous amebic encephalitis (GAE) is a rare and oftentimes fatal disease in immune compromised patients caused by free living amebae Acanthamoeba and Balamuthia. We report a patient in whom GAE secondary to Acanthamoeba was the initial presentation of acquired immunodeficiency syndrome in a 41...

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Bibliographic Details
Published inJournal of neuroimaging Vol. 25; no. 6; p. 1047
Main Authors Dowell, Joshua D, Mukherjee, Sugoto, Raghavan, Prashant, Rehm, Patrice K
Format Journal Article
LanguageEnglish
Published United States 01.11.2015
Subjects
Acanthamoeba - isolation & purification
Acquired Immunodeficiency Syndrome - complications
Acquired Immunodeficiency Syndrome - diagnostic imaging
Adult
Amebiasis - complications
Amebiasis - diagnostic imaging
Fatal Outcome
Humans
Infectious Encephalitis - complications
Infectious Encephalitis - diagnostic imaging
Magnetic Resonance Imaging
Male
Positron-Emission Tomography
Encephalitis
HIV
MRI
FDG
Acquired Immunodeficiency Syndrome (AIDS)
parasitic infections
PET
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Summary:Granulomatous amebic encephalitis (GAE) is a rare and oftentimes fatal disease in immune compromised patients caused by free living amebae Acanthamoeba and Balamuthia. We report a patient in whom GAE secondary to Acanthamoeba was the initial presentation of acquired immunodeficiency syndrome in a 41-year-old male, and discuss the FDG positron emission tomography (PET) and magnetic resonance imaging findings that preceded the pathological diagnosis. The PET results provided complementary information when coupled with the MR brain findings. Improved understanding of the clinical and imaging findings of this deadly disease is the best hope for early diagnosis and treatment of this uncommon but deadly disease.
ISSN:1552-6569
DOI:10.1111/jon.12212