A-kinase anchoring proteins that regulate cardiac remodeling

In response to injury or stress, the adult heart undergoes maladaptive changes, collectively defined as pathological cardiac remodeling. Here, we focus on the role of A-kinase anchoring proteins (AKAPs) in 3 main areas associated with cardiac remodeling and the progression of heart failure: excitati...

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Bibliographic Details
Published inJournal of cardiovascular pharmacology Vol. 58; no. 5; p. 451
Main Authors Carnegie, Graeme K, Burmeister, Brian T
Format Journal Article
LanguageEnglish
Published United States 01.11.2011
Subjects
A Kinase Anchor Proteins - physiology
Animals
Cardiomegaly - metabolism
Excitation Contraction Coupling - physiology
Humans
Sarcomeres - metabolism
Ventricular Remodeling - physiology
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Summary:In response to injury or stress, the adult heart undergoes maladaptive changes, collectively defined as pathological cardiac remodeling. Here, we focus on the role of A-kinase anchoring proteins (AKAPs) in 3 main areas associated with cardiac remodeling and the progression of heart failure: excitation-contraction coupling, sarcomeric regulation, and induction of pathological hypertrophy. AKAPs are a diverse family of scaffold proteins that form multiprotein complexes, integrating cAMP signaling with protein kinases, phosphatases, and other effector proteins. Many AKAPs have been characterized in the heart, where they play a critical role in modulating cardiac function.
ISSN:1533-4023
DOI:10.1097/FJC.0b013e31821c0220