NHLBI-Sponsored Randomized Trial of Postconditioning During Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction

• Published in: Circulation research Vol. 124; no. 5; pp. 769 - 778
• Main Authors: Traverse, Jay H., Swingen, Cory M., Henry, Timothy D., Fox, Jane, Wang, Yale L., Chavez, Ivan J., Lips, Daniel L., Lesser, John R., Pedersen, Wesley R., Burke, Nicholas M., Pai, Akila, Lindberg, Jana L., Garberich, Ross F.
• Format: Journal Article
• Language: English
• Published: United States American Heart Association, Inc 01.03.2019
• Subjects: Aged; Coronary Circulation; Female; Humans; Ischemic Postconditioning - adverse effects; Ischemic Postconditioning - methods; Magnetic Resonance Imaging; Male; Middle Aged; Minnesota; Myocardium - pathology; National Heart, Lung, and Blood Institute (U.S.); Percutaneous Coronary Intervention - adverse effects; Recovery of Function; ST Elevation Myocardial Infarction - diagnostic imaging; ST Elevation Myocardial Infarction - physiopathology; ST Elevation Myocardial Infarction - therapy; Stroke Volume; Time Factors; Tissue Survival; Treatment Outcome; United States; Ventricular Function, Left; Ventricular Remodeling; United States; Minnesota; magnetic resonance imaging; percutaneous coronary intervention; postconditioning; reperfusion injury; myocardial infarction
• ISSN: 0009-7330; 1524-4571; 1524-4571
• DOI: 10.1161/CIRCRESAHA.118.314060

RATIONALE:Postconditioning at the time of primary percutaneous coronary intervention (PCI) for ST-segment–elevation myocardial infarction may reduce infarct size and improve myocardial salvage. However, clinical trials have shown inconsistent benefit. OBJECTIVE:We performed the first National Heart, Lung, and Blood Institute–sponsored trial of postconditioning in the United States using strict enrollment criteria to optimize the early benefits of postconditioning and assess its long-term effects on left ventricular (LV) function. METHODS AND RESULTS:We randomized 122 ST-segment–elevation myocardial infarction patients to postconditioning (4, 30 seconds PTCA [percutaneous transluminal coronary angioplasty] inflations/deflations)+PCI (n=65) versus routine PCI (n=57). All subjects had an occluded major epicardial artery (thrombolysis in myocardial infarction=0) with ischemic times between 1 and 6 hours with no evidence of preinfarction angina or collateral blood flow. Cardiac magnetic resonance imaging measured at 2 days post-PCI showed no difference between the postconditioning group and control in regards to infarct size (22.5±14.5 versus 24.0±18.5 g), myocardial salvage index (30.3±15.6% versus 31.5±23.6%), or mean LV ejection fraction. Magnetic resonance imaging at 12 months showed a significant recovery of LV ejection fraction in both groups (61.0±11.4% and 61.4±9.1%; P<0.01). Subjects randomized to postconditioning experienced more favorable remodeling over 1 year (LV end-diastolic volume =157±34 to 150±38 mL) compared with the control group (157±40 to 165±45 mL; P<0.03) and reduced microvascular obstruction (P=0.05) on baseline magnetic resonance imaging and significantly less adverse LV remodeling compared with control subjects with microvascular obstruction (P<0.05). No significant adverse events were associated with the postconditioning protocol and all patients but one (hemorrhagic stroke) survived through 1 year of follow-up. CONCLUSIONS:We found no early benefit of postconditioning on infarct size, myocardial salvage index, and LV function compared with routine PCI. However, postconditioning was associated with improved LV remodeling at 1 year of follow-up, especially in subjects with microvascular obstruction. CLINICAL TRIAL REGISTRATION:URLhttp://www.clinicaltrials.gov. Unique identifierNCT01324453.