Antimicrobial susceptibility/resistance and molecular epidemiological characteristics of Neisseria gonorrhoeae in 2009 in Belarus

• Published in: APMIS : acta pathologica, microbiologica et immunologica Scandinavica Vol. 119; no. 8; pp. 537 - 542
• Main Authors: GLAZKOVA, SLAVYANA, GOLPARIAN, DANIEL, TITOV, LEONID, PANKRATOVA, NATALIYA, SUHABOKAVA, NATALIYA, SHIMANSKAYA, IRINA, DOMEIKA, MARIUS, UNEMO, MAGNUS
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Publishing Ltd 01.08.2011; Blackwell
• Subjects: Adult; Anti-Infective Agents - pharmacology; Antimicrobial agents; antimicrobial resistance; Azithromycin; Bacteriology; Belarus; Biological and medical sciences; Ceftriaxone; Ciprofloxacin; Data processing; DNA, Bacterial - chemistry; DNA, Bacterial - genetics; Drug resistance; Drug Resistance, Multiple, Bacterial; Eastern Europe; epidemiology; Erythromycin; Female; Fundamental and applied biological sciences. Psychology; Gonorrhea - epidemiology; Gonorrhea - microbiology; Humans; Infectious diseases; Male; Medical sciences; MEDICIN; MEDICINE; Microbial Sensitivity Tests; Microbiology; Miscellaneous; Mosaics; Multilocus Sequence Typing; N. gonorrhoeae multiantigen sequence typing; Neisseria gonorrhoeae; Neisseria gonorrhoeae - drug effects; Neisseria gonorrhoeae - genetics; Neisseria gonorrhoeae - isolation & purification; Phylogeny; Polymerase Chain Reaction; porB gene; Porins - chemistry; Porins - genetics; Republic of Belarus - epidemiology; Spectinomycin; Tetracyclines; Young Adult; Belarus; Eastern Europe; Europe; Republic of Belarus; Typing; Eastern Europe; Neisseriaceae; Belarus; Antimicrobial agent; N; Resistance; epidemiology; Immunology; Neisseria gonorrhoeae; Sensitivity resistance; gonorrhoeae multiantigen sequence typing; antimicrobial resistance; Molecular epidemiology; Bacteria; Micrococcales
• ISSN: 0903-4641; 1600-0463; 1600-0463
• DOI: 10.1111/j.1600-0463.2011.02770.x

Glazkova S, Golparian D, Titov L, Pankratova N, Suhabokava N, Shimanskaya I, Domeika M, Unemo M. Antimicrobial susceptibility/resistance and molecular epidemiological characteristics of Neisseria gonorrhoeae in 2009 in Belarus. APMIS 2011; 119: 537–42. Increased antimicrobial resistance (AMR) in Neisseria gonorrhoeae is a global concern, and ultimately gonorrhoea may become untreatable. Nonetheless, AMR data from East‐Europe are scarce beyond Russia, and no AMR data or other characteristics of gonococci have been reported from Belarus for more than 20 years. The aim was to describe the prevalence of AMR, and report molecular epidemiological characteristics of gonococci circulating in 2009 in Belarus. In a sample of 80 isolates, resistance prevalences to antimicrobials used for gonorrhoea treatment in Belarus were: Ceftriaxone 0%, spectinomycin 0%, azithromycin 17.3%, tetracycline 25.9%, ciprofloxacin 34.6% and erythromycin 59.2%. The isolates displayed no penA mosaic alleles, 38 porB gene sequences and 35 N. gonorrhoeae multiantigen sequence types, of which 20 have not been described before worldwide. Due to the high levels of antimicrobial resistance, only ceftriaxone and spectinomycin can be recommended for empirical treatment of gonorrhoea in Belarus according to WHO recommendations. Continuous gonococcal AMR surveillance in Eastern Europe is crucial. This is now initiated in Belarus using WHO protocols.