Hypoalbuminemia predicts inferior outcome in patients with AIDS-related lymphoma

• Published in: Infectious agents and cancer Vol. 17; no. 1; pp. 1 - 33
• Main Authors: Zhang, Jinxin, Xie, Zhiman, Cai, Shaohang, Qin, Shanfang, Ruan, Guangjing, Lu, Aili, Wu, Yihua, Chen, Juanjuan, Peng, Jie
• Format: Journal Article
• Language: English
• Published: London BioMed Central Ltd 18.06.2022; BioMed Central; BMC
• Subjects: Acquired immune deficiency syndrome; Age; AIDS; AIDS (Disease); AIDS-related lymphoma; Albumin; Biomarkers; Body mass index; Chemotherapy; Correlation analysis; HIV; HIV patients; Human immunodeficiency virus; Immune system; Immunodeficiency; Low income groups; Lymphocytes; Lymphoma; Lymphomas; Malnutrition; Medical prognosis; Medical research; Medicine, Experimental; Multivariate analysis; Overall survival; Patient outcomes; Population; Prognosis; Prognostic factor; Risk factors; Serum albumin; Statistical analysis; Survival; Survival analysis; Tomography; Variance analysis
• ISSN: 1750-9378; 1750-9378
• DOI: 10.1186/s13027-022-00448-w

Abstract Background The prognostic value of serum albumin in acquired immunodeficiency syndrome (AIDS)-related lymphoma (ARL) remains covered. Methods We retrospectively analyzed de novo ARL patients from 2013 to 2019 across three centers. Factors correlated with progression-free survival (PFS) and overall survival (OS) were evaluated in Kaplan–Meier, univariate and multivariate Cox proportional hazard models. Results A total of 86 ARL patients were enrolled with a median follow-up of 34 months. In the cohort, the OS and 2-year PFS rates were 37.5% and 35.4%, respectively. In multivariate models, older age (PFS, hazard ratios [HR] = 1.035, p  = 0.037; OS, HR = 1.034, p  = 0.041) and hypoalbuminemia (OS, HR = 0.910, p  = 0.038) predicted inferior survival. ARL patients with hypoalbuminemia showed worse OS and 2-year PFS ( p  = 0.028 and p  = 0.01, respectively), which was associated with poor Eastern Cooperative Oncology Group performance status (ECOG PS) and higher International Prognosis Index (IPI) score. Conclusion In conclusion, serum albumin at diagnosis is an independent prognostic factor for overall survival in AIDS-related lymphoma.