Clinicopathological characteristics of BRCA-associated breast cancer in Asian patients

BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison with sporadic breast cancer. Asians constitut...

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Bibliographic Details
Published inJournal of pathology and translational medicine Vol. 54; no. 4; pp. 265 - 275
Main Authors Kim, Eun-Kyu, Park, So Yeon, Kim, Sung-Won
Format Journal Article
LanguageEnglish
Published Korea (South) Korean Society of Pathologists, Korean Society for Cytopathology 01.07.2020
The Korean Society of Pathologists and the Korean Society for Cytopathology
대한병리학회
Subjects
Age
Asian people
Breast cancer
Chemotherapy
Clinical trials
Family medical history
Jewish people
Lymphatic system
Mutation
Ovarian cancer
Population
Review
Studies
Tumors
White people
Womens health
병리학
Asia
Genes, BRCA2
Asian Continental Ancestry Group
Breast neoplasms
Genes, BRCA1
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Summary:BRCA1/2 germline mutations account for the majority of hereditary breast cancers. Since the identification of the BRCA genes, several attempts have been made to define the clinicopathological characteristics of BRCA-associated breast cancer in comparison with sporadic breast cancer. Asians constitute 60% of the world population, and although the incidence of breast cancer in Asia remains low compared to the West, breast cancer is the most prevalent female cancer in the region. The epidemiological aspects of breast cancer are different between Asians and Caucasians. Asian patients present with breast cancer at a younger age than Western patients. The contributions of BRCA1/2 mutations to breast cancer incidence are expected to differ between Asians and Caucasians, and the different genetic backgrounds among races are likely to influence the breast cancer phenotypes. However, most large-scale studies on the clinicopathological characteristics of BRCA-associated breast cancer have been on Western patients, while studies on Asian populations were small and sporadic. In this review, we provide an overview of the clinical and pathological characteristics of BRCA-associated breast cancer, incorporating findings on Asian patients.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:2383-7837
2383-7845
DOI:10.4132/jptm.2020.04.07