The Role of lncRNA in the Development of Tumors, including Breast Cancer

Long noncoding RNAs (lncRNAs) are the largest groups of ribonucleic acids, but, despite the increasing amount of literature data, the least understood. Given the involvement of lncRNA in basic cellular processes, especially in the regulation of transcription, the role of these noncoding molecules se...

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Bibliographic Details
Published inInternational journal of molecular sciences Vol. 22; no. 16; p. 8427
Main Authors Smolarz, Beata, Zadrożna-Nowak, Anna, Romanowicz, Hanna
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 05.08.2021
MDPI
Subjects
Breast cancer
Breast carcinoma
Cytoplasm
DNA methylation
expression
Gene expression
Gene regulation
Genetic engineering
Genomes
lncRNA
Mammals
Non-coding RNA
Pathogenesis
Proteins
Review
RNA polymerase
Transcription
Tumors
X chromosomes
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Summary:Long noncoding RNAs (lncRNAs) are the largest groups of ribonucleic acids, but, despite the increasing amount of literature data, the least understood. Given the involvement of lncRNA in basic cellular processes, especially in the regulation of transcription, the role of these noncoding molecules seems to be of great importance for the proper functioning of the organism. Studies have shown a relationship between disturbed lncRNA expression and the pathogenesis of many diseases, including cancer. The present article presents a detailed review of the latest reports and data regarding the importance of lncRNA in the development of cancers, including breast carcinoma.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms22168427