Ferrets: A powerful model of SARS-CoV-2

The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent years not only caused a global pandemic but resulted in enormous social, economic, and health burdens worldwide. Despite considerable efforts to combat coronavirus disease 2019 (COVID-19), various SARS-CoV-2 v...

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Published inDōngwùxué yánjiū Vol. 44; no. 2; pp. 323 - 330
Main Authors Zhao, Yan, Wang, Chang-Le, Gao, Zhi-Yun, Qiao, Hong-Xiu, Wang, Wei-Jie, Liu, Xin-Yan, Chuai, Xia
Format Journal Article
LanguageEnglish
Published China Kunming Institute of Zoology, The Chinese Academy of Sciences 18.03.2023
Subjects
Animal models
Animals
Antiviral agents
Coronaviruses
COVID-19
COVID-19 - veterinary
COVID-19 vaccines
Cricetinae
Disease transmission
Drug development
Enzymes
Ferrets
Hamsters
Infections
Influenza
Medical research
Mice
Mustela
Pandemics
Pathogenesis
Pathogenicity
Pathogens
Peptidyl-Dipeptidase A
Pharmacology
Proteins
SARS-CoV-2
Severe acute respiratory syndrome coronavirus 2
Vaccines
Viral diseases
Viruses
COVID-19
Angiotensin-converting enzyme 2 (ACE2) receptor
Animal models
SARS-CoV-2
Ferret
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Summary:The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in recent years not only caused a global pandemic but resulted in enormous social, economic, and health burdens worldwide. Despite considerable efforts to combat coronavirus disease 2019 (COVID-19), various SARS-CoV-2 variants have emerged, and their underlying mechanisms of pathogenicity remain largely unknown. Furthermore, effective therapeutic drugs are still under development. Thus, an ideal animal model is crucial for studying the pathogenesis of COVID-19 and for the preclinical evaluation of vaccines and antivirals against SARS-CoV-2 and variant infections. Currently, several animal models, including mice, hamsters, ferrets, and non-human primates (NHPs), have been established to study COVID-19. Among them, ferrets are naturally susceptible to SARS-CoV-2 infection and are considered suitable for COVID-19 study. Here, we summarize recent developments and application of SARS-CoV-2 ferret models in studies on pathogenesis, therapeutic agents, and vaccines, and provide a perspective on the role of these models in preventing COVID-19 spread.
ISSN:2095-8137
0254-5853
DOI:10.24272/j.issn.2095-8137.2022.351