CNS pharmacological effects of the total alkaloidal fraction from Albizia inopinata leaves

• Published in: Fitoterapia Vol. 72; no. 2; pp. 124 - 130
• Main Authors: Assis, T.S., Almeida, R.N., Barbosa-Filho, J.M., Medeiros, I.A.
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.02.2001; Elsevier
• Subjects: Albizia inopinata; Animals; Behavior, Animal - drug effects; Biological and medical sciences; Central Nervous System Depressants - pharmacology; CNS depressant activity; General pharmacology; Male; Medical sciences; Mice; Motor Activity - drug effects; Pharmacognosy. Homeopathy. Health food; Pharmacology. Drug treatments; Plant Extracts - pharmacology; Plant Leaves; Plants, Medicinal; Rats; Rats, Wistar; Rosales; South America; Brazil; America; CNS depressant activity; Albizia inopinata; Rat; Pharmacognosy; Rodentia; Plant leaf; Central depressant; Biological activity; Medicinal plant; Vertebrata; Mammalia; Leguminosae; Mouse; Dicotyledones; Animal; Angiospermae; Albizia; Plant origin; Tree; Spermatophyta
• ISSN: 0367-326X
• DOI: 10.1016/S0367-326X(00)00268-9

The total alkaloidal fraction of Albizia inopinata leaves (FLA) was investigated for its central nervous system (CNS) effects. FLA (10 mg/kg, i.p.) significantly reduced (45%) the locomotor activity in mice. In addition, it inhibited the conditioned avoidance response behavior and induced ptosis in rats. On the other hand, FLA did not exert significant effect on catalepsy, but potentiated the haloperidol-induced catalepsy. No effect was observed on sleep induced by sodium pentobarbital or apomorphine-induced stereotypes.