Phagocytosis and the Inflammatory Response
Macrophages are a cornerstone of the innate immune system. They detect infectious organisms via a plethora of receptors, phagocytose them, and orchestrate an appropriate host response. Phagocytosis is extraordinarily complex: numerous receptors stimulate particle internalization, the cytoskeletal el...
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Published in | The Journal of infectious diseases Vol. 187; no. Supplement-2; pp. S340 - 5 |
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Main Author | |
Format | Journal Article Conference Proceeding |
Language | English |
Published |
Chicago, IL
The University of Chicago Press
15.06.2003
University of Chicago Press Oxford University Press |
Subjects | |
Online Access | Get full text |
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Summary: | Macrophages are a cornerstone of the innate immune system. They detect infectious organisms via a plethora of receptors, phagocytose them, and orchestrate an appropriate host response. Phagocytosis is extraordinarily complex: numerous receptors stimulate particle internalization, the cytoskeletal elements mediating internalization differ by receptor system and the nature of the pathogen being internalized, and the outcome can differ by bacterium. After generating a panel of 150 monoclonal antibodies that recognizes proteins recruited to the phagosome, analysis of novel phagocytic proteins was prioritized by focusing on those that behave differently during the internalization of virulent and avirulent bacteria. Several novel proteins that have roles in membrane extension were characterized. Although the inflammatory pathways leading to appropriate host response are reasonably well defined, it is not clear how macrophages define the threat precisely. Recent work indicates that Toll-like receptors play a key role in reading a “bar code” on invading microorganisms and in eliciting a specific immune response. The mechanisms and coupling to the phagocytic response are discussed. |
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Bibliography: | ark:/67375/HXZ-MS6B632L-H istex:940EAC3E3251FF25C2F190B3B21FC82404A47664 ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2 |
ISSN: | 0022-1899 1537-6613 |
DOI: | 10.1086/374747 |