The role of thiamine in HIV infection

Summary Patients infected with HIV have a high prevalence of thiamine deficiency. Genetic studies have provided the opportunity to determine which proteins link thiamine to HIV pathology, i.e., renin–angiotensin system, poly(ADP-ribosyl) polymerase 1, Sp1 promoter gene, transcription factor p53, apo...

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Published inInternational journal of infectious diseases Vol. 17; no. 4; pp. e221 - e227
Main Authors Lương, Khanh vinh quốc, Nguyễn, Lan Thi Hoàng
Format Journal Article
LanguageEnglish
Published Canada Elsevier Ltd 01.04.2013
Subjects
HIV
HIV Infections - physiopathology
Human immunodeficiency virus
Humans
Infectious Disease
Pulmonary/Respiratory
Thiamine
Thiamine - physiology
Thiamine Deficiency - physiopathology
Transketolase
Vitamin B1
Vitamin B1
Human immunodeficiency virus
HIV
Transketolase
Thiamine
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Summary:Summary Patients infected with HIV have a high prevalence of thiamine deficiency. Genetic studies have provided the opportunity to determine which proteins link thiamine to HIV pathology, i.e., renin–angiotensin system, poly(ADP-ribosyl) polymerase 1, Sp1 promoter gene, transcription factor p53, apoptotic factor caspase 3, and glycogen synthetase kinase 3β. Thiamine also affects HIV through non-genomic factors, i.e., matrix metalloproteinase, vascular endothelial growth factor, heme oxygenase 1, the prostaglandins, cyclooxygenase 2, reactive oxygen species, and nitric oxide. In conclusion, thiamine may benefit HIV patients, but further investigation of the role of thiamine in HIV infection is needed.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
content type line 23
ObjectType-Review-1
ISSN:1201-9712
1878-3511
DOI:10.1016/j.ijid.2012.11.019