Hypovitaminosis D predicts the onset of orthostatic hypotension in older adults

• Published in: Journal of the American Society of Hypertension Vol. 10; no. 9; pp. 724 - 732
• Main Authors: Veronese, Nicola, MD, Trevisan, Caterina, MD, Bolzetta, Francesco, MD, De Rui, Marina, MD, Zambon, Sabina, MD, Musacchio, Estella, ScD, Sartori, Leonardo, MD, Stubbs, Brendon, PhD, Perissinotto, Egle, ScD, Crepaldi, Gaetano, MD, Manzato, Enzo, MD, Sergi, Giuseppe, MD
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.09.2016
• Subjects: Age Factors; Aged; Aged, 80 and over; Blood Pressure Determination; Cardiovascular; Cohort Studies; Cross-Sectional Studies; Female; Follow-Up Studies; Humans; Hypotension, Orthostatic - diagnosis; Hypotension, Orthostatic - etiology; Male; orthostatic hypotension; Risk Factors; Sex Factors; vitamin D; Vitamin D - analogs & derivatives; Vitamin D - blood; Vitamin D Deficiency - complications; orthostatic hypotension; vitamin D; Aged
• ISSN: 1933-1711; 1878-7436
• DOI: 10.1016/j.jash.2016.06.038

Abstract A number of small cross sectional studies have demonstrated that hypovitaminosis D (represented by low 25 hydroxyvitamin D (25OHD) levels) is associated with orthostatic hypotension (OH). We investigated if hypovitaminosis D is associated with the onset of OH in older adults over a follow-up of 4.4 years. 25OHD was categorized using sex-specific quartiles; OH was defined as a drop of ≤20 mm Hg in systolic or ≤10 mm Hg in diastolic blood pressure <3 minutes of standing. Among 1308 elderly without OH at baseline, using an adjusted logistic regression analysis and taking those with higher baseline serum 25OHD as reference, there was a significant increase in the onset of OH in those with lower serum 25OHD levels. The association was significant only in women when we stratified by sex. In conclusion, hypovitaminosis D predicts the onset of OH in older adults, particularly in women.