Loading and Release of Phenolic Compounds Present in Mexican Oregano (Lippia graveolens) in Different Chitosan Bio-Polymeric Cationic Matrixes

Mexican oregano (Lippia graveolens) polyphenols have antioxidant and anti-inflammatory potential, but low bioaccessibility. Therefore, in the present work the micro/nano-encapsulation of these compounds in two different matrixes of chitosan (CS) and chitosan-b-poly(PEGMA2000) (CS-b-PPEGMA) is descri...

Full description

Saved in:
Bibliographic Details
Published inPolymers Vol. 14; no. 17; p. 3609
Main Authors Garcia-Carrasco, Melissa, Picos-Corrales, Lorenzo A, Gutiérrez-Grijalva, Erick P, Angulo-Escalante, Miguel A, Licea-Claverie, Angel, Heredia, J. Basilio
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2022
MDPI
Subjects
Acids
Aluminum
Antioxidants
bioaccessibility
Bioavailability
Biopolymers
Cationic polymerization
Caustic soda
Chitosan
Chloride
Encapsulation
Flavonoids
Functional foods & nutraceuticals
Metabolites
nanoencapsulation
Oregano
phenolic compounds
Phenols
Phytochemicals
Polyethylene glycol
polyethylene glycol methacrylate
Polymers
Polyphenols
Potassium
Supramolecular compounds
Mexico
United Kingdom
United States > US
Online AccessGet full text

Cover

More Information
Summary:Mexican oregano (Lippia graveolens) polyphenols have antioxidant and anti-inflammatory potential, but low bioaccessibility. Therefore, in the present work the micro/nano-encapsulation of these compounds in two different matrixes of chitosan (CS) and chitosan-b-poly(PEGMA2000) (CS-b-PPEGMA) is described and assessed. The particle sizes of matrixes of CS (~955 nm) and CS-b-PPEGMA (~190 nm) increased by 10% and 50%, respectively, when the phenolic compounds were encapsulated, yielding loading efficiencies (LE) between 90–99% and 50–60%, correspondingly. The release profiles in simulated fluids revealed a better control of host–guest interactions by using the CS-b-PPEGMA matrix, reaching phenolic compounds release of 80% after 24 h, while single CS retained the guest compounds. The total reducing capacity (TRC) and Trolox equivalent antioxidant capacity (TEAC) of the phenolic compounds (PPHs) are protected and increased (more than five times) when they are encapsulated. Thus, this investigation provides a standard encapsulation strategy and relevant results regarding nutraceuticals stabilization and their improved bioaccessibility.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:2073-4360
2073-4360
DOI:10.3390/polym14173609