Perinatal risk factors for bronchopulmonary dysplasia in a national cohort of very-low-birthweight infants

• Published in: American journal of obstetrics and gynecology Vol. 208; no. 2; pp. 115.e1 - 115.e9
• Main Authors: Klinger, Gil, MD, Sokolover, Nir, MD, Boyko, Valentina, MSc, Sirota, Lea, MD, Lerner-Geva, Liat, MD, PhD, Reichman, Brian, MBChB
• Format: Journal Article
• Language: English
• Published: United States Mosby, Inc 01.02.2013
• Subjects: Adolescent; Adult; bronchopulmonary dysplasia; Bronchopulmonary Dysplasia - epidemiology; Cardiopulmonary Resuscitation; Cohort Studies; Female; Gestational Age; Humans; Infant; Infant, Newborn; Infant, Very Low Birth Weight; Israel - epidemiology; Male; Maternal Age; Obstetrics and Gynecology; Peripartum Period; Pregnancy; Pregnancy Complications - epidemiology; preterm infant; Prospective Studies; Risk Factors; Sex Factors; very-low-birthweight; Young Adult; Israel; risk factors; preterm infant; bronchopulmonary dysplasia; very-low-birthweight
• ISSN: 0002-9378; 1097-6868
• DOI: 10.1016/j.ajog.2012.11.026

Objective We sought to assess the independent effect of perinatal factors on the risk for bronchopulmonary dysplasia (BPD) in very-low-birthweight infants. Study Design This was a population-based observational study. Data were prospectively collected by the Israel Neonatal Network. Multivariable analyses identified independent risk factors for BPD. Results Of 12,139 infants surviving to a postmenstrual age of 36 weeks, 1663 (13.7%) developed BPD. BPD was independently associated with young maternal age (odds ratio [OR], 1.53), maternal hypertensive disorders (OR, 1.28), antepartum hemorrhage (OR, 1.26), male gender (OR, 1.41), non-Jewish ethnicity (OR, 1.23), birth defects (OR, 1.94), small for gestational age (GA) (OR, 2.65), and delivery room resuscitation (OR, 1.86). Stratified analysis by GA groups showed that postdelivery resuscitation had a more pronounced effect with increasing maturity. Conclusion Perinatal factors and pregnancy complications were independently associated with development of BPD in very-low-birthweight infants. Most risk factors identified were consistent within GA groups.