Coronary artery involvement early and late after radiofrequency current application in young pigs
Radiofrequency current (500 kHz) was delivered by temperature guidance (75° C) over a 30-second period in 10 young piglets with a steerable 6F electrode catheter equipped with a thermistor at the 4 mm tip electrode. Lesions were created at the right atrial aspect of the tricuspid valve anulus, at th...
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Published in | The American heart journal Vol. 133; no. 4; pp. 436 - 440 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
New York, NY
Mosby, Inc
01.04.1997
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | Radiofrequency current (500 kHz) was delivered by temperature guidance (75° C) over a 30-second period in 10 young piglets with a steerable 6F electrode catheter equipped with a thermistor at the 4 mm tip electrode. Lesions were created at the right atrial aspect of the tricuspid valve anulus, at the left ventricular myocardium under the lateral mitral valve anulus, and at the left ventricular apex. After 48 hours, five animals were randomly sacrificed. Lesions in the five animals appeared as transmural gray-white coagulation necrosis. Lymphocytic infiltration around the right atrial lesions extended into the layers of the right coronary artery in four of five animals. After 6 months, lesions consisted of compact fibrous tissue in the remaining five animals. Right atrial lesions extended to the layers of the right coronary artery in four of five pigs. In two animals the lumen of the right coronary artery was narrowed because of intimal thickening by 25% and 40%, respectively. No increase in the lesion size was observed with the growth of the animals. Effects on the right coronary artery as a late sequela after radiofrequency current application may also be possible in human beings and should be considered when radiofrequency current ablation procedures are proposed in infants and young children. (Am Heart J 1997;133:436-40.) |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 0002-8703 1097-6744 |
DOI: | 10.1016/S0002-8703(97)70185-6 |