Efficient reductive dehydration of primary amides to nitriles catalyzed by hydrido thiophenolato iron(II) complexes under hydrosilation conditions

The reductive dehydration of amides to nitriles under hydrosilation conditions with hydrido thiophenolato iron(II) complexes [cis-Fe(H)(SAr)(PMe3)4] (1–4) as catalysts is reported using (EtO)3SiH as an efficient reducing agent in the yields up to 93%. The merits of this catalytic system, the low cat...

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Published inCatalysis communications Vol. 86; pp. 148 - 150
Main Authors Xue, Benjing, Sun, Hongjian, Wang, Yan, Zheng, Tingting, Li, Xiaoyan, Fuhr, Olaf, Fenske, Dieter
Format Journal Article
LanguageEnglish
Published Elsevier B.V 05.11.2016
Subjects
Amide
Dehydration
Iron hydride
Nitrile
Silane
Amide
Nitrile
Dehydration
Iron hydride
Silane
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Summary:The reductive dehydration of amides to nitriles under hydrosilation conditions with hydrido thiophenolato iron(II) complexes [cis-Fe(H)(SAr)(PMe3)4] (1–4) as catalysts is reported using (EtO)3SiH as an efficient reducing agent in the yields up to 93%. The merits of this catalytic system, the low catalyst loadings (2mol%) and the amount of efficient reducing agent (EtO)3SiH, make this method more attractive. [Display omitted] •Hydrido thiophenolato iron(II) complexes.•The reductive dehydration of amides to nitriles.•(EtO)3SiH as a reducing agent.
ISSN:1566-7367
1873-3905
DOI:10.1016/j.catcom.2016.08.024