Discrimination and Integration of Stress Signals by Pathogenic Bacteria

For pathogenic bacteria, the ability to sense and respond to environmental stresses encountered within the host is critically important, allowing them to adapt to changing conditions and express virulence genes appropriately. This review considers the diverse molecular mechanisms by which stress con...

Full description

Saved in:
Bibliographic Details
Published inCell host & microbe Vol. 20; no. 2; pp. 144 - 153
Main Authors Fang, Ferric C., Frawley, Elaine R., Tapscott, Timothy, Vázquez-Torres, Andrés
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 10.08.2016
Subjects
Adaptation, Physiological
Bacterial Physiological Phenomena
Bacterial Proteins - chemistry
Bacterial Proteins - metabolism
Host-Pathogen Interactions
Signal Transduction
Stress, Physiological
Online AccessGet full text

Cover

More Information
Summary:For pathogenic bacteria, the ability to sense and respond to environmental stresses encountered within the host is critically important, allowing them to adapt to changing conditions and express virulence genes appropriately. This review considers the diverse molecular mechanisms by which stress conditions are sensed by bacteria, how related signals are discriminated, and how stress responses are integrated, highlighting recent studies in selected bacterial pathogens of clinical relevance. Pathogenic bacteria must recognize and distinguish among a variety of stress conditions during their associations with mammalian hosts. This review discusses molecular mechanisms that allow pathogenic bacteria to discriminate among closely related stress signals and strategies that enable bacteria to integrate diverse signals within common regulatory circuits.
ISSN:1931-3128
1934-6069
DOI:10.1016/j.chom.2016.07.010