Integration of calcium and RAS signalling

Calcium is a universal intracellular signal that is responsible for controlling a plethora of cellular processes. Understanding how such a simple ion can regulate so many diverse cellular processes is a key goal of calcium- and cell-biologists. One molecule that is sensitive to changes in intracellu...

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Bibliographic Details
Published inNature reviews. Molecular cell biology Vol. 3; no. 5; pp. 339 - 348
Main Authors Cullen, Peter J, Lockyer, Peter J
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.05.2002
Subjects
Biologists
Calcium
Calcium - physiology
Cell growth
Kinases
MAP Kinase Signaling System - physiology
Neurons - physiology
Plasma
Proteins
ras GTPase-Activating Proteins - physiology
ras Guanine Nucleotide Exchange Factors - physiology
ras Proteins - physiology
ras-GRF1 - physiology
Signal Transduction - physiology
Son of Sevenless Proteins - physiology
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Summary:Calcium is a universal intracellular signal that is responsible for controlling a plethora of cellular processes. Understanding how such a simple ion can regulate so many diverse cellular processes is a key goal of calcium- and cell-biologists. One molecule that is sensitive to changes in intracellular calcium levels is Ras. This small GTPase operates as a binary molecular switch, and regulates cell proliferation and differentiation. Here, we focus on examining the link between calcium and Ras signalling and, in particular, we speculate as to how the complexity of calcium signalling could regulate Ras activity.
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ISSN:1471-0072
1471-0080
DOI:10.1038/nrm808