Current Knowledge of Long Non-Coding RNA HOTAIR in Breast Cancer Progression and Its Application

Breast cancer is one of the most devastating cancers with high morbidity and mortality in females worldwide. Breast tumorigenesis and further development present great uncertainty and complexity, and efficient therapeutic approaches still lack. Accumulating evidence indicates HOX transcript antisens...

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Published inLife (Basel, Switzerland) Vol. 11; no. 6; p. 483
Main Authors Shi, Yubo, Huang, Qingyun, Kong, Xinyu, Zhao, Ruichen, Chen, Xinyue, Zhai, Yujia, Xiong, Lixia
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 26.05.2021
MDPI
Subjects
Antisense RNA
Antisense therapy
Apoptosis
Biomarkers
Breast cancer
Cell growth
Cell migration
Cell proliferation
competitive endogenous RNA
Drug resistance
Epidermal growth factor
Estrogens
Gene expression
HOTAIR
Kinases
lncRNA
Medical prognosis
Metastasis
miRNA
Morbidity
Non-coding RNA
progression
Proteins
Review
Therapeutic targets
Transcription
Transcription factors
Tumorigenesis
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Summary:Breast cancer is one of the most devastating cancers with high morbidity and mortality in females worldwide. Breast tumorigenesis and further development present great uncertainty and complexity, and efficient therapeutic approaches still lack. Accumulating evidence indicates HOX transcript antisense intergenic RNA (HOTAIR) is dysregulated in cancers and has emerged as a novel hotspot in the field. In breast cancer, aberrant HOTAIR expression is responsible for advanced tumor progression by regulating multifarious signaling pathways. Besides, HOTAIR may act as competitive endogenous RNA to bind to several microRNAs and suppress their expressions, which can subsequently upregulate the levels of targeted downstream messenger RNAs, thereby leading to further cancer progression. In addition, HOTAIR works as a promising biomarker and predictor for breast cancer patients’ diagnosis or outcome prediction. Recently, HOTAIR is potentially considered to be a drug target. Here, we have summarized the induction of HOTAIR in breast cancer and its impacts on cell proliferation, migration, apoptosis, and therapeutic resistance, as well as elucidating the underlying mechanisms. This review aims to provide new insights into investigations between HOTAIR and breast cancer development and inspire new methods for studying the association in depth.
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These authors contributed equally to this work.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11060483