Diapause-like Drug-Tolerant Persister State: The Key to Nirvana Rebirth

• Published in: Medicina (Kaunas, Lithuania) Vol. 60; no. 2; p. 228
• Main Authors: Chen, Han-Lin, Jin, Wei-Lin
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 01.01.2024
• Subjects: Animals; Autophagy; Biomarkers; cancer relapse; Cancer therapies; Chemotherapy; Diapause; dormancy; Drug resistance; drug-tolerant persister; Drugs; Epigenetics; Fibroblasts; Health aspects; Humans; Kinases; Neoplasms - drug therapy; Senescence; Signal transduction; Stem cells; Tumors; drug-tolerant persister; diapause; cancer relapse; drug resistance; dormancy
• ISSN: 1648-9144; 1010-660X; 1648-9144
• DOI: 10.3390/medicina60020228

Cancer is one of the leading causes of death in the world. Various drugs have been developed to eliminate it but to no avail because a tumor can go into dormancy to avoid therapy. In the past few decades, tumor dormancy has become a popular topic in cancer therapy. Recently, there has been an important breakthrough in the study of tumor dormancy. That is, cancer cells can enter a reversible drug-tolerant persister (DTP) state to avoid therapy, but no exact mechanism has been found. The study of the link between the DTP state and diapause seems to provide an opportunity for a correct understanding of the mechanism of the DTP state. Completely treating cancer and avoiding dormancy by targeting the expression of key genes in diapause are possible. This review delves into the characteristics of the DTP state and its connection with embryonic diapause, and possible treatment strategies are summarized. The authors believe that this review will promote the development of cancer therapy.