IGFBP2 in cancer: Pathological role and clinical significance (Review)

The versatility of IGFBP2, as a secreted protein in cancer cells or a cytoplasmic signaling effector, has been extensively investigated in many malignant cancers. Over the last few decades, IGFBP2, a key member of the IGFBP family, has been identified as an important oncogene in multiple human cance...

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Published inOncology reports Vol. 45; no. 2; pp. 427 - 438
Main Authors Wei, Lai-Feng, Weng, Xue-Fen, Huang, Xu-Chun, Peng, Yu-Hui, Guo, Hai-Peng, Xu, Yi-Wei
Format Journal Article
LanguageEnglish
Published Greece Spandidos Publications 01.02.2021
Spandidos Publications UK Ltd
Subjects
Angiogenesis
Binding sites
Brain cancer
Breast cancer
Cancer
Clinical significance
Development and progression
Gene expression
Genetic aspects
Liver cancer
Melanoma
Metastasis
Neuroblastoma
Phosphatase
Proteins
Skin cancer
Stem cells
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Summary:The versatility of IGFBP2, as a secreted protein in cancer cells or a cytoplasmic signaling effector, has been extensively investigated in many malignant cancers. Over the last few decades, IGFBP2, a key member of the IGFBP family, has been identified as an important oncogene in multiple human cancers. In addition, a growing number of studies have shown that IGFBP2 is greatly elevated in serum or tissue in patients with malignant tumors and plays an essential role in several key oncogenic processes, such as tumor cellular proliferation, migration, invasion, angiogenesis, epithelial‑to‑mesenchymal transition, and immunoregulation, which are involved in a variety of signal pathways, usually via an IGF‑independent means. Moreover, growing evidence indicates that aberrant overexpression of IGFBP2 may serve as a useful biomarker for the diagnosis and prognosis of patients, as well as act as a potential therapeutic target for the management of clinical treatment in patients with malignant disease. In the present review, we summarize the current points of view that IGFBP2 performs a role in the initiation and progression of various types of cancer by interacting with several key molecules involved in cancer signaling pathways. We also discuss its potential clinical application value as a diagnostic/prognostic biomarker for patients with malignant tumors.
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ISSN:1021-335X
1791-2431
DOI:10.3892/or.2020.7892