Cutaneous reactions to COVID-19 vaccines: A review
The increasing number of reports on cutaneous reactions following COVID-19 vaccination has led to growing concerns among certain groups. We reviewed the published reports of cutaneous lesions after COVID-19 vaccination. We conducted a literature search for original and review articles published betw...
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Published in | JAAD international Vol. 7; pp. 178 - 186 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
Elsevier Inc
01.06.2022
Elsevier |
Subjects | |
Online Access | Get full text |
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Summary: | The increasing number of reports on cutaneous reactions following COVID-19 vaccination has led to growing concerns among certain groups.
We reviewed the published reports of cutaneous lesions after COVID-19 vaccination.
We conducted a literature search for original and review articles published between January 1, 2020, and September 27, 2021.
Eleven cutaneous reactions associated with COVID-19 vaccines were determined; the most prevalent reactions were local injection site reactions, delayed local reactions, urticaria, angioedema, and morbilliform eruptions. There were more reports on skin reactions following the administration of messenger RNA-based vaccines than on those following the administration of adenoviral vector or inactivated whole-virus vaccines, in part, due to their higher administration rate. Most reported skin reactions occurred after the first vaccine dose.
A reporting bias could not be excluded, and skin biopsy results were not available for most included individuals. Moreover, given that the included trials focused on vaccine efficacy, there was a lack of details concerning cutaneous reactions and participant information.
Not all cutaneous reactions observed after COVID-19 vaccination are hypersensitivity reactions. Different cutaneous reactions may reflect underlying immune responses to the vaccines. A large majority of COVID-19 vaccination reactions were mild and self-limiting, and people should be encouraged to complete their vaccination regimen. |
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Bibliography: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
ISSN: | 2666-3287 2666-3287 |
DOI: | 10.1016/j.jdin.2022.01.011 |