Leukaemic Presentation of Small-Cell Alk-Positive Anaplastic Large Cell Lymphoma in a Young Woman—Report of a Case with 9-Year Survival

Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positiv...

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Published inMedicina (Kaunas, Lithuania) Vol. 59; no. 9; p. 1628
Main Authors Santonja, Carlos, Morillo-Giles, Daniel, Prieto-Pareja, Elena, Soto-de Ozaeta, Carlos, Serrano-del Castillo, Cristina, Salgado-Sánchez, Rocío, Yi-Shi, Ana-Wu-Yang, Manso, Rebeca, Rodríguez-Pinilla, Socorro María
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 01.09.2023
MDPI
Subjects
ALK positive survival
Aluminum compounds
anaplastic large cell lymphoma
Biopsy
Bone marrow
Cancer
Case Report
Case reports
Chemotherapy
Crizotinib
Disease
Epstein-Barr virus
Infections
leukaemic
Leukemia
Liver
Lymphatic diseases
Lymphatic system
Lymphocytes
Lymphoma
Patients
Skin
Spleen
Steroids
Transplants & implants
Vincristine
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Summary:Anaplastic large cell lymphoma (ALCL) with leukaemic presentation (either ab initio or along the course of the disease) has been rarely reported. Irrespective of ALK expression in the neoplastic cells, it features a dismal prognosis. We report a rare case of leukaemic, small cell variant ALK-positive ALCL with 9-year survival in a young woman who was treated upfront with corticosteroids and standard chemotherapy, and review thoroughly the previously published cases. Such an unexpected, good outcome hints at the existence of different clinical subgroups in the leukaemic variant of ALK-positive ALCL.
ISSN:1648-9144
1010-660X
1648-9144
DOI:10.3390/medicina59091628