Current Overview on the Use of Mesenchymal Stem Cells for Perianal Fistula Treatment in Patients with Crohn’s Disease

Perianal fistula in patients with Crohn’s disease is an extremely challenging condition. The disease tends to reoccur, and with current treatment options, a large number of patients are left with active ailment and experience major morbidity. In recent years, hopeful results regarding local use of m...

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Published inLife (Basel, Switzerland) Vol. 11; no. 11; p. 1133
Main Authors Włodarczyk, Marcin, Czerwińska, Katarzyna, Włodarczyk, Jakub, Fichna, Jakub, Dziki, Adam, Dziki, Łukasz
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 25.10.2021
MDPI
Subjects
Abscesses
Cell culture
Crohn's disease
Dendritic cells
Disease
Fecal incontinence
Fistula
Fistulae
Inflammation
Medical research
Mesenchymal stem cells
Morbidity
Patients
perianal Crohn’s disease
perianal fistula
Review
Side effects
Stem cells
Systematic review
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Summary:Perianal fistula in patients with Crohn’s disease is an extremely challenging condition. The disease tends to reoccur, and with current treatment options, a large number of patients are left with active ailment and experience major morbidity. In recent years, hopeful results regarding local use of mesenchymal stem cells (MSCs) in perianal Crohn’s disease have been published. Although to this day there are no clear guidelines determining optimal dosage, injections frequency and culture conditions, their efficiency has proven to be much higher than conventionally used methods. According to studies, they can effectively induce as well as maintain fistula closure. This approach also avoids common side effects related to conventional surgical treatment.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:2075-1729
2075-1729
DOI:10.3390/life11111133