COMPLICATION OF OLIGURIC ACUTE RENAL FAILURE IN PATIENTS TREATED WITH LOW-MOLECULAR WEIGHT DEXTRAN
Acute renal failure (ARF) is a well-documented but infrequent complication in patients treated with low-molecular weight dextran (LMWD). We herein report 3 cases of oliguric ARF following the administration of dextran-40. One case developed ARF totally after 1.200 g of LMWD administration. In contra...
Saved in:
Published in | Renal failure Vol. 23; no. 5; pp. 679 - 684 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
Colchester
Informa UK Ltd
01.01.2001
Taylor & Francis |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | Acute renal failure (ARF) is a well-documented but infrequent complication in patients treated with low-molecular weight dextran (LMWD). We herein report 3 cases of oliguric ARF following the administration of dextran-40. One case developed ARF totally after 1.200 g of LMWD administration. In contrast, two cases having increased serum creatinine developed oliguria despite the acceptable therapeutic doses (totally 450 and 650 g). Contrast media was also co-administered in these patients. Plasma exchange (PE), double filtration plasmapheresis (DFPP), or continuous hemodiafiltration (CHDF) but not hemodialysis (HD) reduced circulating dextran concentrations by 35-44% during a single session. All patients completely recovered from ARF by 14-32 days after the treatment. Our cases suggested that radiocontrast could predispose to the development of LMWD-induced ARF especially in patients having pre-existing renal dysfunction. In addition, PE, DFPP and CHDF afforded a beneficial effect for removing accumulated LMWD from the circulation. |
---|---|
ISSN: | 0886-022X 1525-6049 |
DOI: | 10.1081/JDI-100107364 |