Somatic Rearrangement in B Cells: It’s (Mostly) Nuclear Physics

We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection. Nuclear architecture and AID-mediated selection drive gene rearrangements in B cell...

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Bibliographic Details
Published inCell Vol. 162; no. 4; pp. 708 - 711
Main Authors Aiden, Erez Lieberman, Casellas, Rafael
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 13.08.2015
Subjects
Animals
B-Lymphocytes - cytology
B-Lymphocytes - metabolism
CCCTC-Binding Factor
Cell Nucleus - genetics
Cell Nucleus - metabolism
Gene Rearrangement, B-Lymphocyte
Humans
Lymphocyte Activation
Repressor Proteins - metabolism
V(D)J Recombination
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Summary:We discuss how principles of nuclear architecture drive typical gene rearrangements in B lymphocytes, whereas translocation hot spots and recurrent lesions reflect the extent of AID-mediated DNA damage and selection. Nuclear architecture and AID-mediated selection drive gene rearrangements in B cells.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:0092-8674
1097-4172
DOI:10.1016/j.cell.2015.07.034