Electrochemical reduction of metronidazole at activated glassy carbon electrode and its determination in pharmaceutical dosage forms

• Published in: Journal of pharmaceutical and biomedical analysis Vol. 17; no. 2; pp. 299 - 305
• Main Authors: Ozkan, S A, Ozkan, Y, Sentürk, Z
• Format: Journal Article
• Language: English
• Published: Amsterdam Elsevier B.V 01.06.1998; Elsevier Science
• Subjects: Activated glassy carbon electrode; Analysis; Antitrichomonal Agents - analysis; Antitrichomonal Agents - chemistry; Biological and medical sciences; Drug analysis; Electrochemistry; General pharmacology; Hydrogen-Ion Concentration; Medical sciences; Metronidazole; Metronidazole - analysis; Metronidazole - chemistry; Oxidation-Reduction; Pharmacology. Drug treatments; Solutions - analysis; Suppositories - analysis; Suspensions - analysis; Tablets - analysis; Voltammetry; Voltammetry; Activated glassy carbon electrode; Metronidazole; Drug analysis; Chemical reduction; Antiprotozoal agent; Imidazole derivatives; Antifungal agent; Parasiticid; Electrochemistry; Carbon electrode; Dosage form; Activation; Quantitative analysis
• ISSN: 0731-7085; 1873-264X
• DOI: 10.1016/S0731-7085(97)00202-1

A voltammetric method has been developed for the determination of metronidazole in dosage forms. The method is based on the electrochemical reduction of the drug at a glassy carbon electrode activated by applying a new pretreatment. The influence of pH, concentration, scan rate and presence of organic solvent and surfactant has been studied. The current is proportional to the concentration and permits the drug to be determined in the concentration range 2×10 −6–6×10 −4 M in Britton-Robinson buffer (pH 10). Furthermore, results obtained by the proposed method have been compared with USP XXIII procedure which involves a HPLC method.