Saccular Impairment in Alzheimer's Disease Is Associated with Driving Difficulty

• Published in: Dementia and geriatric cognitive disorders Vol. 44; no. 5-6; p. 294
• Main Authors: Wei, Eric X, Oh, Esther S, Harun, Aisha, Ehrenburg, Matthew, Agrawal, Yuri
• Format: Journal Article
• Language: English
• Published: Switzerland 01.01.2017
• Subjects: Aged; Aged, 80 and over; Alzheimer Disease - pathology; Alzheimer Disease - psychology; Automobile Driving - psychology; Cognition; Cognitive Dysfunction - psychology; Cross-Sectional Studies; Female; Humans; Male; Neuropsychological Tests; Prospective Studies; Saccule and Utricle - pathology; Space Perception; Surveys and Questionnaires; Vestibular Function Tests; Saccule and utricle; Vestibular system; Alzheimer’s disease; Automobile driving; Spatial cognition
• ISSN: 1421-9824
• DOI: 10.1159/000485123

Patients with Alzheimer's disease (AD) experience increased rates of vestibular loss. Recent studies suggest that saccular impairment in mild cognitive impairment (MCI) and AD patients is associated with impaired spatial cognitive function. However, the impact of saccular impairment on everyday behaviors that rely on spatial cognitive function is unknown. We recruited 60 patients (21 MCI and 39 AD) from an interdisciplinary Memory Clinic. Saccular function was measured, and a visuospatial questionnaire was administered to assess whether participants experienced impairments in terms of driving difficulty, losing objects, falls, and fear of falling. In multiple logistic regression analyses, MCI and AD patients with bilateral saccular impairment had a significant, greater than 12-fold odds of driving difficulty (OR 12.1, 95% CI 1.2, 117.7) compared to MCI and AD patients with normal saccular function, and the association appears to be mediated by spatial cognition as measured by the Money Road Map Test. This study suggests a novel link between saccular impairment and driving difficulty in MCI and AD patients and demonstrates that driving difficulty may be a real-world manifestation of impaired spatial cognition associated with saccular impairment.