Comparative study on in vivo response of porous calcium carbonate composite ceramic and biphasic calcium phosphate ceramic

• Published in: Materials Science & Engineering C Vol. 64; pp. 117 - 123
• Main Authors: He, Fupo, Ren, Weiwei, Tian, Xiumei, Liu, Wei, Wu, Shanghua, Chen, Xiaoming
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.07.2016
• Subjects: Animals; Biocompatibility; Bone formation; Bone graft; Bone Substitutes - chemistry; Bone Substitutes - pharmacology; Bones; Calcium carbonate; Calcium Carbonate - chemistry; Calcium Carbonate - pharmacology; Calcium phosphate; Ceramics; Ceramics - chemistry; Ceramics - pharmacology; Degradation; Femur; Grafting; Hydroxyapatites - chemistry; Hydroxyapatites - pharmacology; In vivo methods and tests; Male; Materials Testing; Porosity; Rabbits; Degradation; Calcium phosphate; Bone formation; Bone graft; Calcium carbonate
• ISSN: 0928-4931; 1873-0191; 1873-0191
• DOI: 10.1016/j.msec.2016.03.085

In a previous study, robust calcium carbonate composite ceramics (CC/PG) were prepared by using phosphate-based glass (PG) as an additive, which showed good cell response. In the present study the in vivo response of porous CC/PG was compared to that of porous biphasic calcium phosphate ceramics (BCP), using a rabbit femoral critical-size grafting model. The materials degradation and bone formation processes were evaluated by general observation, X-ray radiography, micro-computed tomography, and histological examination. The results demonstrated excellent biocompatibility and osteoconductivity, and progressive degradation of CC/PG and BCP. Although the in vitro degradation rate of CC/PG was distinctly faster than that of BCP, at 4week post-implantation, the bone generation and material degradation of CC/PG were less than those of BCP. Nevertheless, at postoperative week 8, the increment of bone formation and material degradation of CC/PG was pronouncedly larger than that of BCP. These results show that CC/PG is a potential resorbable bone graft aside from the traditional synthetic ones. [Display omitted] •A calcium carbonate composite ceramic (CC/PG) was acquired.•The in vivo response of CC/PG and biphasic calcium phosphate (BCP) was compared.•CC/PG showed faster in vitro degradation rate compared to BCP.•CC/PG showed less in vivo degradation and bone formation than BCP at week 4.•CC/PG had larger increment of degradation and bone formation than BCP at week 8.