The changing spectrum of disease, etiology, and diagnosis of mucormycosis

During the 20 year interval from 1958 through 1978 a change in the spectrum of disease, etiology, and diagnosis of mucormycosis was observed at The Mount Sinai Hospital. Although the rhinocerebral and pulmonary forms of mucormycosis were still the most frequent forms of disease, hospital acquired cu...

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Published inHuman pathology Vol. 11; no. 5; pp. 457 - 464
Main Authors Marchevsky, Alberto M., Bottone, Edward J., Geller, Stephen A., Giger, Donald K.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 01.01.1980
Subjects
Acute Disease
Adolescent
Adult
Aged
Antibodies, Fungal - analysis
Diabetes Complications
Female
Humans
Infant, Newborn
Leukemia - complications
Lung - pathology
Male
Middle Aged
Mucormycosis - complications
Mucormycosis - diagnosis
Nose - pathology
Rhizopus - immunology
Rhizopus - isolation & purification
Skin - pathology
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Summary:During the 20 year interval from 1958 through 1978 a change in the spectrum of disease, etiology, and diagnosis of mucormycosis was observed at The Mount Sinai Hospital. Although the rhinocerebral and pulmonary forms of mucormycosis were still the most frequent forms of disease, hospital acquired cutaneous and subcutaneous infections emerged. Since 1974, 14 of 15 cases of mucormycosis were diagnosed during life. Rhizopus species, especially R. rhizopodoformis, have been the etiologic agents identified in 13 of 14 culturally proven cases. The presence or absence of antirhizopus fungistatic activity and antirhizopus antibody in the sera of six of the patients was correlated with the severity of clinical disease. Preliminary results showed a relationship between the extent of disease and the degree of serum fungistatic activity that was independent of antibody production.
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ISSN:0046-8177
1532-8392
DOI:10.1016/S0046-8177(80)80054-2