Germline Energetics, Aging, and Female Infertility

The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian function is being driven by recent evidence that mammalian females routinely generate new oocytes during adult life through the activity of germ...

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Published inCell metabolism Vol. 17; no. 6; pp. 838 - 850
Main Authors Tilly, Jonathan L., Sinclair, David A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 04.06.2013
Subjects
Aging - metabolism
Animals
Caloric Restriction
Female
Germ Cells
Humans
Infertility, Female - metabolism
Menopause - metabolism
Mice
Mitochondria - metabolism
Oocytes
Oogenesis
Ovary - cytology
Ovary - metabolism
Rats
Stem Cells
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Abstract The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian function is being driven by recent evidence that mammalian females routinely generate new oocytes during adult life through the activity of germline stem cells. In this perspective, we overview the female reproductive system as a powerful and clinically relevant model to understand links between aging and metabolism, and we discuss new concepts for how oocytes and their precursor cells might be altered metabolically to sustain or increase ovarian function and fertility in women.
AbstractList The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian function is being driven by recent evidence that mammalian females routinely generate new oocytes during adult life through the activity of germline stem cells. In this perspective, we overview the female reproductive system as a powerful and clinically relevant model to understand links between aging and metabolism, and we discuss new concepts for how oocytes and their precursor cells might be altered metabolically to sustain or increase ovarian function and fertility in women.
Author Sinclair, David A.
Tilly, Jonathan L.
AuthorAffiliation 3 Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
1 Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA
4 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
2 Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA
AuthorAffiliation_xml – name: 2 Department of Obstetrics, Gynecology and Reproductive Biology, Harvard Medical School, Boston, MA 02115, USA
– name: 4 Department of Genetics, Harvard Medical School, Boston, MA 02115, USA
– name: 1 Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA
– name: 3 Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
Author_xml – sequence: 1
  givenname: Jonathan L.
  surname: Tilly
  fullname: Tilly, Jonathan L.
  email: jtilly@partners.org
  organization: Vincent Center for Reproductive Biology, Massachusetts General Hospital, Boston, MA 02114, USA
– sequence: 2
  givenname: David A.
  surname: Sinclair
  fullname: Sinclair, David A.
  email: david_sinclair@hms.harvard.edu
  organization: Glenn Laboratories for the Biological Mechanisms of Aging, Harvard Medical School, Boston, MA 02115, USA
BackLink https://www.ncbi.nlm.nih.gov/pubmed/23747243$$D View this record in MEDLINE/PubMed
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Snippet The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian...
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SubjectTerms Aging - metabolism
Animals
Caloric Restriction
Female
Germ Cells
Humans
Infertility, Female - metabolism
Menopause - metabolism
Mice
Mitochondria - metabolism
Oocytes
Oogenesis
Ovary - cytology
Ovary - metabolism
Rats
Stem Cells
Title Germline Energetics, Aging, and Female Infertility
URI https://dx.doi.org/10.1016/j.cmet.2013.05.007
https://www.ncbi.nlm.nih.gov/pubmed/23747243
https://search.proquest.com/docview/1366575945
https://pubmed.ncbi.nlm.nih.gov/PMC3756096
Volume 17
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