Germline Energetics, Aging, and Female Infertility

The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian function is being driven by recent evidence that mammalian females routinely generate new oocytes during adult life through the activity of germ...

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Bibliographic Details
Published inCell metabolism Vol. 17; no. 6; pp. 838 - 850
Main Authors Tilly, Jonathan L., Sinclair, David A.
Format Journal Article
LanguageEnglish
Published United States Elsevier Inc 04.06.2013
Subjects
Aging - metabolism
Animals
Caloric Restriction
Female
Germ Cells
Humans
Infertility, Female - metabolism
Menopause - metabolism
Mice
Mitochondria - metabolism
Oocytes
Oogenesis
Ovary - cytology
Ovary - metabolism
Rats
Stem Cells
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Summary:The role of metabolism in ovarian aging is poorly described, despite the fact that ovaries fail earlier than most other organs. Growing interest in ovarian function is being driven by recent evidence that mammalian females routinely generate new oocytes during adult life through the activity of germline stem cells. In this perspective, we overview the female reproductive system as a powerful and clinically relevant model to understand links between aging and metabolism, and we discuss new concepts for how oocytes and their precursor cells might be altered metabolically to sustain or increase ovarian function and fertility in women.
Bibliography:ObjectType-Article-2
SourceType-Scholarly Journals-1
ObjectType-Feature-3
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ObjectType-Review-1
ISSN:1550-4131
1932-7420
DOI:10.1016/j.cmet.2013.05.007