Adenocarcinoma Arising from Chronic Perianal Crohn's Disease: Case Report and Review of the Literature

• Published in: The American surgeon Vol. 74; no. 1; pp. 59 - 61
• Main Authors: Smith, Richard, Hicks, David, Tomljanovich, Paul I., Lele, Shashikant B., Rajput, Ashwani, Bullard Dunn, Kelli
• Format: Journal Article
• Language: English
• Published: Atlanta, GA Southeastern Surgical Congress 01.01.2008; SAGE PUBLICATIONS, INC
• Subjects: Adenocarcinoma, Mucinous - etiology; Adenocarcinoma, Mucinous - pathology; Adenocarcinoma, Mucinous - surgery; Aged; Anus Neoplasms - etiology; Anus Neoplasms - pathology; Anus Neoplasms - surgery; Biological and medical sciences; Bowel disease; Chronic Disease; Colorectal cancer; Crohn Disease - complications; Crohn Disease - pathology; Crohn Disease - surgery; Crohn's disease; Female; Gastroenterology. Liver. Pancreas. Abdomen; General aspects; Humans; Literature reviews; Medical sciences; Other diseases. Semiology; Patients; Rectal Fistula - etiology; Rectal Fistula - pathology; Rectal Fistula - surgery; Stomach. Duodenum. Small intestine. Colon. Rectum. Anus; Adenocarcinoma; Chronic disease; Malignant tumor; Inflammatory disease; Case study; Medicine; Crohn disease; Chronic; Treatment; Perianal; Surgery; Digestive diseases; Intestinal disease; Bibliographic review; Cancer
• ISSN: 0003-1348; 1555-9823
• DOI: 10.1177/000313480807400113

Perianal disease is a common manifestation of Crohn's disease. Rarely malignancy arises in perianal fistulas. The etiology of fistula related cancer remains a subject of debate. We present a unique case of a perianal Crohn's disease with adenomatous epithelialization of a fistula tract and an associated mucinous adenocarcinoma. Our case demonstrates that mucinous adenocarcinoma can arise in long standing perianal Crohn's disease and may be associated with adenomatous transformation of the epithelial lining of the fistula tract.