Prognostic Impact of Tumor-Associated Macrophages on Long-Term Oncologic Outcomes in Colorectal Cancer

This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgica...

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Published inLife (Basel, Switzerland) Vol. 11; no. 11; p. 1240
Main Authors Shin, Hyeong Chan, Seo, Incheol, Jeong, Hasong, Byun, Sang Jun, Kim, Shin, Bae, Sung Uk, Kwon, Sun Young, Lee, Hye Won
Format Journal Article
LanguageEnglish
Published Basel MDPI AG 16.11.2021
MDPI
Subjects
Antibodies
Antigens
Cancer
CD11c antigen
CD163 antigen
Colorectal cancer
Colorectal carcinoma
Cytokines
Datasets
Gene expression
Immunohistochemistry
Lymphatic system
Macrophages
Medical prognosis
Medical research
Metastases
prognosis
Surgery
Survival
Survival analysis
tumor microenvironment
tumor-associated macrophages
Tumors
United States > US
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Summary:This study evaluated the correlation between tumor-associated macrophages (TAMs) and long-term oncologic outcomes in colorectal cancer (CRC). We evaluated TAMs based on the expression of CD68, CD11c, and CD163 as optimal markers via immunohistochemistry in 148 patients with CRC who underwent surgical resection between September 1999 and August 2004. A high proportion of CD68-positive macrophages were associated with the occurrence of distant metastasis. A low proportion of CD11c-positive macrophages were associated with unfavorable overall survival (OS) and disease-free survival. CD11c-positive macrophages were found to act as independent prognostic factors for OS. An analysis of our long-term data indicated that TAMs are significantly associated with OS and prognosis in CRC.
Bibliography:ObjectType-Article-1
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Hyeong Chan Shin and Incheol Seo contributed equally to this work.
ISSN:2075-1729
2075-1729
DOI:10.3390/life11111240