Inhibitory effects of polyphenols from water chestnut (Trapa japonica) husk on glycolytic enzymes and postprandial blood glucose elevation in mice

Water chestnut is an annual aquatic plant that grows in Asia and Europe. Although water chestnut has been used as food and herbal medicine, its physiological functions and active ingredients are unknown. Here, we extracted polyphenols from the husk of the Japanese water chestnut (Trapa japonica) and...

Full description

Saved in:
Bibliographic Details
Published inFood chemistry Vol. 165; pp. 42 - 49
Main Authors YASUDA, Midori, YASUTAKE, Kenichiro, HINO, Madoka, OHWATARI, Hitomi, OHMAGARI, Nozomi, TAKEDOMI, Kazumi, TANAKA, Takashi, NONAKA, Gen-Ichiro
Format Journal Article
LanguageEnglish
Published Kidlington Elsevier 15.12.2014
Subjects
Animals
Biological and medical sciences
Blood Glucose - drug effects
Food toxicology
Lythraceae - chemistry
Male
Medical sciences
Mice
Phytotherapy
Plant Extracts - pharmacology
Plants, Medicinal - chemistry
Polyphenols - pharmacology
Postprandial Period
Toxicology
Water
Blood glucose
Biological fluid
Glucose
Blood
Glycolytic enzyme
Polyphenol
Chestnut
Carbohydrate
Proanthocyanidin
α-Amylase
Enzyme
Postprandial
Rodentia
Glycosylases
Micronutrient
Vertebrata
Mammalia
Mouse
α-Glucosidase
Water chestnut
Glycosidases
Animal
Plant origin
Phenols
Hydrolases
Trapa japonica
Online AccessGet full text

Cover

More Information
Summary:Water chestnut is an annual aquatic plant that grows in Asia and Europe. Although water chestnut has been used as food and herbal medicine, its physiological functions and active ingredients are unknown. Here, we extracted polyphenols from the husk of the Japanese water chestnut (Trapa japonica) and assessed their effects on blood glucose levels. Three hydrolysable polyphenolics (WCPs), eugeniin, 1,2,3,6-tetra-O-galloyl-β-d-glucopyranose, and trapain, were predominant with dry-weight contents of 2.3 ± 0.0, 2.7 ± 0.1, and 1.2 ± 0.1g/100g, respectively. These WCPs exhibited inhibitory activity against α-amylase and α-glucosidase. Whereas (-)-epigallocatechin gallate does not inhibit α-amylase, WCPs exhibited high inhibitory activity (>80% at 0.15 mg/mL). In mice, administration of WCPs (40 mg/kg) significantly reduced blood glucose and serum insulin levels as assessed by the carbohydrate tolerance test.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0308-8146
1873-7072
DOI:10.1016/j.foodchem.2014.05.083