Interleukin-13 gene polymorphisms at −1055 C/T and +2044 G/A positions in patients with squamous cell carcinoma of head and neck

• Published in: Brazilian journal of otorhinolaryngology Vol. 78; no. 5; pp. 64 - 68
• Main Authors: Khademi, Bijan, Hashemi, Seyed Basir, Ghaderi, Abbass, Shahrestani, Ali, Mohammadianpanah, Mohammad
• Format: Journal Article
• Language: English
• Published: Brazil Elsevier Editora Ltda 01.09.2012; Elsevier
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; carcinoma; Carcinoma, Squamous Cell - genetics; Case-Control Studies; Female; Gene Frequency; genetic; Genetic Predisposition to Disease; Genotype; head and neck neoplasms; Head and Neck Neoplasms - genetics; Humans; il-13; Interleukin-13 - genetics; Male; Middle Aged; Original; Polymerase Chain Reaction; polymorphism; Polymorphism, Genetic; Polymorphism, Restriction Fragment Length; Promoter Regions, Genetic - genetics; squamous cell; Young Adult; genetic; head and neck neoplasms; polymorphism; carcinoma; il-13; squamous cell
• ISSN: 1808-8694; 1808-8686
• DOI: 10.5935/1808-8694.20120010

Squamous cell carcinoma (SCC) is the most common malignancy that involves the upper aerodigestive tract. Interleukin-13 (IL-13) is an immunoregulatory cytokine that has been reported to have some polymorphisms in it gene associated with same disease especially asthma and allergy. The present study aimed to investigate whether the polymorphisms of IL-13 gene (at positions of 1055C/T in the promoter of 1L-13 gene and +2044G/T exon-4) differ in patients with head and neck SCC from healthy controls. This study was investigated in patient with head and neck SCC (n = 137) and age- and sex-matched healthy controls (n = 127). Genotyping of IL-13 gene polymorphism was performed using polymerase chain reaction-based restriction fragment length polymorphism method. No statistically significant differences were found in the frequencies of genotypes and alleles between patients and control group at both sites (p = 0.16). In addition, no association was observed between investigated genotypes and other potential prognostic factors such as age, sex, primary tumor site, tumor size and smoking. This study suggests that there is no association between IL-13 gene polymorphisms (at position −1055C/T and +2044GI A) and susceptibility of the patients to SCC of head and neck.